1,3- dihydroxy- 2- hydroxymethylpropyl- 2- ammonium 2- ((R)- 3- cyclo- hexyl- 1- phenylpropyl)- 1,3- dioxo- 2,3- dihydro- 1H- isoindole- 5- carboxylate monohydrate
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Bio-Agent Context: Research Results
Experts
Related Diseases
| 1. | Dermatitis
07/01/2005
- " These results indicate that JTP-27536 is an inhibitor of Igs, in particular IgE, and of IL-5, which has antiallergic properties in mouse dermatitis model, and suggest that an inhibitor of Igs and IL-5 like JTP-27536 may be useful as a drug for the treatment of allergic diseases." 07/01/2005
- " JTP-27536 [(+)-1,3-dihydroxy-2-hydroxymethylpropyl-2-ammonium 2-[(R)-3-cyclo-hexyl-1-phenylpropyl]-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylate monohydrate], a novel inhibitor of immunoglobulins and interleukin-5 with anti-inflammatory properties in mouse allergic dermatitis model." 07/01/2005
- " In vivo animal experiments using dinitrophenylated ascaris-sensitized mice and 2,4,6-trinitro-1-chrolobenzene-induced chronic dermatitis mice showed that JTP-27536 was more potent than suplatast tosilate and comparable with prednisolone in inhibiting ear swelling, antigen-specific IgE and IL-5 production, and cell infiltrations into the inflamed tissue. "
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