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3'-C-methyladenosine

structure in first source

Also Known As:

3'-Me-Ado

Networked: 2 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purine Nucleosides: 360
        Adenosine: 12431
        3'-C-methyladenosine: 2
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleosides: 6847
  - Purine Nucleosides: 360
    - Adenosine: 12431
      - 3'-C-methyladenosine: 2
  - Ribonucleosides: 49
    - Adenosine: 12431
      - 3'-C-methyladenosine: 2

Experts

1.	Cappellacci, Loredana: 2 articles (07/2008 - 07/2005)
2.	Franchetti, Palmarisa: 2 articles (07/2008 - 07/2005)
3.	Grifantini, Mario: 2 articles (07/2008 - 07/2005)
4.	Jayaram, Hiremagalur N: 2 articles (07/2008 - 07/2005)
5.	Petrelli, Riccardo: 2 articles (07/2008 - 07/2005)
6.	Szekeres, Thomas: 2 articles (07/2008 - 07/2005)
7.	Vita, Patrizia: 2 articles (07/2008 - 07/2005)
8.	Graser, Geraldine: 1 article (07/2008)
9.	Lavecchia, Antonio: 1 article (07/2008)
10.	Saiko, Philipp: 1 article (07/2008)

Related Diseases

1.	Carcinoma (Carcinomatosis) 07/24/2008 - "The SAR study confirms that an unsubstituted N (6)-amino group is essential for optimal cytotoxicity of 3'-Me-Ado against both K562 and carcinoma cell lines. " 07/24/2008 - "N (6)-(+/-)- endo-2-norbornyl-3'- C-methyladenosine ( 7) was found to be the most cytotoxic compound, with GI 50 values slightly higher than that of 3'-Me-Ado against K562 and carcinoma cell lines and 2.7 fold higher cytotoxicity against human promyelocytic leukemia HL-60 cells. " 07/28/2005 - "From this study 3'-C-methyladenosine (3'-Me-Ado) emerged as the most active compound, showing activity against human myelogenous leukemia K562, multidrug resistant human leukemia K562IU, human promyelocytic leukemia HL-60, human colon carcinoma HT-29, and human breast carcinoma MCF-7 cell lines with IC(50) values ranging from 11 to 38 muM. "
2.	Leukemia 07/24/2008 - "N (6)-(+/-)- endo-2-norbornyl-3'- C-methyladenosine ( 7) was found to be the most cytotoxic compound, with GI 50 values slightly higher than that of 3'-Me-Ado against K562 and carcinoma cell lines and 2.7 fold higher cytotoxicity against human promyelocytic leukemia HL-60 cells. " 07/28/2005 - "From this study 3'-C-methyladenosine (3'-Me-Ado) emerged as the most active compound, showing activity against human myelogenous leukemia K562, multidrug resistant human leukemia K562IU, human promyelocytic leukemia HL-60, human colon carcinoma HT-29, and human breast carcinoma MCF-7 cell lines with IC(50) values ranging from 11 to 38 muM. "
3.	Myeloid Leukemia (Leukemia, Myelocytic) 07/28/2005 - "From this study 3'-C-methyladenosine (3'-Me-Ado) emerged as the most active compound, showing activity against human myelogenous leukemia K562, multidrug resistant human leukemia K562IU, human promyelocytic leukemia HL-60, human colon carcinoma HT-29, and human breast carcinoma MCF-7 cell lines with IC(50) values ranging from 11 to 38 muM. "
4.	Breast Neoplasms (Breast Cancer) 07/28/2005 - "From this study 3'-C-methyladenosine (3'-Me-Ado) emerged as the most active compound, showing activity against human myelogenous leukemia K562, multidrug resistant human leukemia K562IU, human promyelocytic leukemia HL-60, human colon carcinoma HT-29, and human breast carcinoma MCF-7 cell lines with IC(50) values ranging from 11 to 38 muM. "