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isocephaeline

terpenoid tetrahydroisoquinoline alkaloid from Psychotria klugii; structure in first source

Also Known As:

10-O-demethylisocephaeline

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - isocephaeline: 1
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Isoquinolines: 34
      - Tetrahydroisoquinolines: 44
        isocephaeline: 1

Experts

1.	Dunbar, D Chuck: 1 article (06/2005)
2.	Jones, Deborah K: 1 article (06/2005)
3.	Kim, Yong-Pil: 1 article (06/2005)
4.	Mohammed, Kaleem Asjad: 1 article (06/2005)
5.	Muhammad, Ilias: 1 article (06/2005)
6.	Nagle, Dale G: 1 article (06/2005)
7.	Zhou, Yu-Dong: 1 article (06/2005)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 06/01/2005 - "Klugine (1), isocephaeline (2), and emetine (4) inhibited hypoxia-inducible factor-1 (HIF-1) activation by hypoxia in T47D breast tumor cells (IC(50) values 0.2, 1.1, and 0.11 muM, respectively). " 06/01/2005 - "Terpenoid tetrahydroisoquinoline alkaloids emetine, klugine, and isocephaeline inhibit the activation of hypoxia-inducible factor-1 in breast tumor cells."
2.	Hypoxia (Hypoxemia) 06/01/2005 - "Klugine (1), isocephaeline (2), and emetine (4) inhibited hypoxia-inducible factor-1 (HIF-1) activation by hypoxia in T47D breast tumor cells (IC(50) values 0.2, 1.1, and 0.11 muM, respectively). " 06/01/2005 - "Terpenoid tetrahydroisoquinoline alkaloids emetine, klugine, and isocephaeline inhibit the activation of hypoxia-inducible factor-1 in breast tumor cells."

Related Drugs and Biologics

1.	Terpenes (Terpenoids)
2.	Emetine
3.	Alkaloids
4.	klugine
5.	1,2,3,4-tetrahydroisoquinoline