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orazipone

inhibits cytokine production and histamine release; an NSAID

Also Known As:

OR 1384; OR-1384; OR1384

Networked: 4 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Sulfhydryl Compounds: 4168
    - orazipone: 4

Experts

1.	Nissinen, Erkki: 3 articles (02/2008 - 01/2005)
2.	Kankaanranta, Hannu: 2 articles (02/2008 - 06/2006)
3.	Moilanen, Eeva: 2 articles (02/2008 - 06/2006)
4.	Hämäläinen, Mari: 1 article (02/2008)
5.	Sareila, Outi: 1 article (02/2008)
6.	Boerma, Marjan: 1 article (10/2006)
7.	Hauer-Jensen, Martin: 1 article (10/2006)
8.	Richter, Konrad K: 1 article (10/2006)
9.	Wang, Junru: 1 article (10/2006)
10.	Ilmarinen, Pinja: 1 article (06/2006)

Related Diseases

1.	Radiation Injuries (Radiation Sickness) 10/01/2006 - "Orazipone, a locally acting immunomodulator, ameliorates intestinal radiation injury: a preclinical study in a novel rat model."
2.	Necrosis 06/01/2006 - "Orazipone further enhanced spontaneous apoptosis as well as that induced by CD95 ligation without inducing primary necrosis. " 01/01/2005 - "Orazipone, OR-1958 and budesonide inhibited significantly and dose dependently tumour necrosis factor-alpha production in HMC-1 cells with IC50-values of 20, 10, and 0.25 microM, respectively. "
3.	Asthma (Bronchial Asthma) 06/01/2006 - "Our results suggest that orazipone and its derivative OR-2370 possess strong antieosinophilic activity and thus may have anti-inflammatory efficacy in the treatment of asthma and/or allergic conditions." 02/01/2008 - "Orazipone [OR-1384; 3-[4-(methylsulfonyl)benzylidene]pentane-2,4-dione] is a novel sulfhydryl-modulating compound that has anti-inflammatory properties in experimental models of asthma and inflammatory bowel disease. "
4.	Chronic Obstructive Pulmonary Disease (COPD) 01/01/2005 - "Orazipone (OR-1384) and OR-1958 are novel anti-inflammatory sulfhydryl reactive compounds with potential applications in the treatment of chronic obstructive lung disease and colitis. "
5.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 02/01/2008 - "Orazipone [OR-1384; 3-[4-(methylsulfonyl)benzylidene]pentane-2,4-dione] is a novel sulfhydryl-modulating compound that has anti-inflammatory properties in experimental models of asthma and inflammatory bowel disease. "

Related Drugs and Biologics

1.	Immunologic Factors (Immunomodulators)
2.	orazipone
3.	Budesonide (Pulmicort)
4.	Cytokines
5.	3- (4- chloro- 3- nitrobenzylidene)pentane- 2,4- dione
6.	OR 1958
7.	pentane

Related Therapies and Procedures

1.	Ligation