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N- bis- (3- phenyl- propyl)9- oxo- fluorene- 2,7- diamide

GPI 16552 considered a potentially specific PARG inhibitor

Also Known As:

GPI 16552

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Fluorenes: 7
        N-bis-(3-phenyl-propyl)9-oxo-fluorene-2,7-diamide: 3
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Fluorenes: 7
    - N-bis-(3-phenyl-propyl)9-oxo-fluorene-2,7-diamide: 3

Experts

1.	Zhang, Jie: 3 articles (01/2007 - 07/2003)
2.	Li, Jia-He: 2 articles (01/2007 - 07/2003)
3.	Massuda, Edmond: 2 articles (01/2007 - 07/2003)
4.	Li, Weixing: 2 articles (12/2005 - 07/2003)
5.	Crisafulli, Concetta: 1 article (01/2007)
6.	Cuzzocrea, Salvatore: 1 article (01/2007)
7.	Di Paola, Rosanna: 1 article (01/2007)
8.	Esposito, Emanuela: 1 article (01/2007)
9.	Genovese, Tiziana: 1 article (01/2007)
10.	Malleo, Giuseppe: 1 article (01/2007)

Related Diseases

1.	Brain Infarction 07/18/2003 - "We demonstrate that either pre- or post-ischemia treatment with 40 mg/kg of N-bis-(3-phenyl-propyl)9-oxo-fluorene-2,7-diamide, a novel PARG inhibitor, significantly reduces brain infarct volumes by 40-53% in a rat model of focal cerebral ischemia. "
2.	Neoplasm Metastasis (Metastasis) 12/01/2005 - "The results indicated that combined treatment with GPI 16552 and TMZ significantly reduced melanoma growth, increased life-span of mice bearing tumour at the CNS site, and decreased the ability of melanoma cells to form lung metastases and to invade the extracellular matrix. "
3.	Experimental Melanoma 12/01/2005 - "The PARG inhibitor N-bis-(3-phenyl-propyl)9-oxo-fluorene-2,7-diamide (GPI 16552) was administered in combination with TMZ to mice injected subcutaneously or intracranially with B16 melanoma cells. "
4.	Melanoma (Melanoma, Malignant) 12/01/2005 - "The results indicated that combined treatment with GPI 16552 and TMZ significantly reduced melanoma growth, increased life-span of mice bearing tumour at the CNS site, and decreased the ability of melanoma cells to form lung metastases and to invade the extracellular matrix. "
5.	Ischemia 07/18/2003 - "We demonstrate that either pre- or post-ischemia treatment with 40 mg/kg of N-bis-(3-phenyl-propyl)9-oxo-fluorene-2,7-diamide, a novel PARG inhibitor, significantly reduces brain infarct volumes by 40-53% in a rat model of focal cerebral ischemia. "

Related Drugs and Biologics

1.	N- bis- (3- phenyl- propyl)9- oxo- fluorene- 2,7- diamide
2.	2,4-dinitrofluorobenzene sulfonic acid