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Aristoforin

derivative of hyperforin, is a potent anticancer agent; structure in first source

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Aristoforin: 3
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        Phloroglucinol: 132
        Aristoforin: 3

Experts

1.	Fedoročko, P: 1 article (07/2016)
2.	Jendželovský, R: 1 article (07/2016)
3.	Šemeláková, M: 1 article (07/2016)
4.	Fedoročko, Peter: 1 article (12/2012)
5.	Jendželovský, Rastislav: 1 article (12/2012)
6.	Mikeš, Jaromír: 1 article (12/2012)
7.	Šemeláková, Martina: 1 article (12/2012)
8.	Bruyère, Françoise: 1 article (07/2009)
9.	Gartner, Michael: 1 article (07/2009)
10.	Giannis, Athanassios: 1 article (07/2009)

Related Diseases

1.	Colonic Neoplasms (Colon Cancer) 12/05/2012 - "The logic of this combination is based on the fact that both bioactive compounds naturally occur in plants of Hypericum sp. At relatively low concentrations up to 5 μM, hyperforin and aristoforin were able to stimulate onset of apoptosis in HT-29 colon adenocarcinoma cells exposed to HY-PDT, inhibit cell cycle progression, suppress expression of matrixmetalloproteinases-2/-9 together with cell adhesivity, thereby affecting the clonogenic potential of the cells. " 12/05/2012 - "The pro-apoptotic and anti-invasive effects of hypericin-mediated photodynamic therapy are enhanced by hyperforin or aristoforin in HT-29 colon adenocarcinoma cells." 07/01/2016 - "Drug membrane transporters and CYP3A4 are affected by hypericin, hyperforin or aristoforin in colon adenocarcinoma cells."
2.	Neoplasms (Cancer) 07/01/2009 - "Hyperforin and aristoforin inhibit lymphatic endothelial cell proliferation in vitro and suppress tumor-induced lymphangiogenesis in vivo."

Related Drugs and Biologics

1.	hyperforin
2.	hypericin
3.	Cytochrome P-450 CYP3A
4.	Membrane Transport Proteins (Biological Pump)
5.	1-phenyl-3,3-dimethyltriazene (PDT)

Related Therapies and Procedures

1.	Photochemotherapy (Photodynamic Therapy)