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MCS-C2

synthetic analog of pyrrolo(2,3-d-pyrimidine nucleoside toyocamycin and sangivamycin; structure in first source

Networked: 3 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleosides: 6847
  - Ribonucleosides: 49
    - Toyocamycin: 28
      - MCS-C2: 3

Experts

1.	Lee, Chul-Hoon: 3 articles (02/2010 - 06/2005)
2.	Cho, Youl-Hee: 2 articles (05/2006 - 06/2005)
3.	Kim, Min Kyoung: 2 articles (05/2006 - 06/2005)
4.	Kang, Jeonghwa: 1 article (02/2010)
5.	Lee, Dong-Keun: 1 article (02/2010)
6.	Moon, Sang-Ik: 1 article (05/2006)
7.	Park, Hae Young: 1 article (05/2006)
8.	Chun, Moon Woo: 1 article (06/2005)
9.	Kim, Jung Mogg: 1 article (06/2005)
10.	Lee, Seung Ki: 1 article (06/2005)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 05/01/2006 - "The purpose of the present study was to investigate the mechanisms involved in the antiproliferative and apoptotic effects of MCS-C2, a novel analog of the pyrrolo[2,3-d]pyrimidine nucleoside toyocamycin and sangivamycin, in human prostate cancer LNCaP cells. "
2.	Lung Neoplasms (Lung Cancer) 02/01/2010 - "This study was aimed to evaluate the molecular mechanisms on cell cycle arrest and apoptotic induction of MCS-C2 in human lung cancer A549 cells. " 02/01/2010 - "In conclusion, based on these results, we suggest that MCS-C2 may be a potent cancer chemotherapeutic candidate for use in treating human lung cancer cells via up-regulation and activation of p53." 02/01/2010 - "Cell cycle arrest and cytochrome c-mediated apoptotic induction in human lung cancer A549 cells by MCS-C2, an analogue of sangivamycin."
3.	Leukemia 06/08/2005 - "Induction of apoptosis in human leukemia cells by MCS-C2 via caspase-dependent Bid cleavage and cytochrome c release." 06/08/2005 - "The purpose of the present study was to investigate the anti-proliferative and apoptotic effects of MCS-C2, a novel synthetic analogue of the pyrrolo[2,3-d]pyrimidine nucleoside toyocamycin and sangivamycin, in human promyelocytic leukemia (HL-60) cells. "
4.	Neoplasms (Cancer) 06/08/2005 - "However, MCS-C2 showed almost no antiproliferative effect and no apoptotic induction in normal lymphocyte cells used as a control when compared with those in HL-60 cancer cells. " 02/01/2010 - "In conclusion, based on these results, we suggest that MCS-C2 may be a potent cancer chemotherapeutic candidate for use in treating human lung cancer cells via up-regulation and activation of p53."

Related Drugs and Biologics

1.	sangivamycin
2.	Toyocamycin
3.	Nucleosides
4.	pyrimidine
5.	Cytochromes c (Cytochrome c)
6.	Caspases