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FR217840

matrix metalloproteinase inhibitor; structure in first source

Also Known As:

(2R)-1-((5-(4-fluorophenyl)-2-thienyl)sulfonyl)-N-hydroxy-4-(methylsulfonyl)-2-piperazinecarboxamide

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperazines: 26
    - FR217840: 1

Experts

1.	Hirayama, Yoshitaka: 1 article (01/2005)
2.	Imamura, Yoshimasa: 1 article (01/2005)
3.	Imanishi, Junko: 1 article (01/2005)
4.	Ishikawa, Takeshi: 1 article (01/2005)
5.	Minoura, Kyoko: 1 article (01/2005)
6.	Miyata, Susumu: 1 article (01/2005)
7.	Mizutani, Tsuyoshi: 1 article (01/2005)
8.	Mutoh, Seitaro: 1 article (01/2005)
9.	Neya, Masahiro: 1 article (01/2005)
10.	Nishigaki, Fusako: 1 article (01/2005)

Related Diseases

1.	Inflammation (Inflammations) 01/31/2005 - "Although oral administration (days 1-21) of FR217840 (3.2, 10, 32 mg/kg) to adjuvant injected Lewis rats did not affect inflammation, as indicated by both hind paw swelling and histological inflammatory infiltration, FR217840 suppressed both bone destruction and serum pyridinoline content in a dose-dependent manner. "
2.	Arthritis (Polyarthritis) 01/31/2005 - "We studied the effect of FR217840 on a rat adjuvant induced arthritis model. " 01/31/2005 - "Also, FR217840 (32 mg/kg) reduced tartrate-resistant acid phosphatase (TRAP) cell number in the ankle joints of rats with arthritis. " 01/31/2005 - "Prevention of progressive joint destruction in adjuvant induced arthritis in rats by a novel matrix metalloproteinase inhibitor, FR217840."

Related Drugs and Biologics

1.	Matrix Metalloproteinase Inhibitors
2.	Tartrate-Resistant Acid Phosphatase
3.	pyridinoline

Related Therapies and Procedures

1.	Oral Administration