dimethicone (dimethyl polysiloxane)

01/01/2017 - "Our findings suggest that the dimeticone could provide a safe and effective treatment for tungiasis in areas with difficult access to health care. "
01/01/2021 - "Six clinical trials evaluated topical products for the treatment of tungiasis; 2 evaluated dimeticone-based compounds and reported positive results in lesion reduction and cure. "
10/30/2023 - "The Effectiveness of Topical Dimethicone Together with a One Health Approach for the Control of Tungiasis in the Sanumás Communities, Yanomami Territory, Amazon Rainforest: A Real-World Study."
01/01/2014 - "Treatment of Tungiasis with dimeticone: a proof-of-principle study in rural Kenya."
10/30/2023 - "Only three cases of tungiasis resulted in active lesions after the use of topical dimethicone together with the One Health approach, with two cases of recurrence. "

01/01/2021 - "It is recommended dimeticone lotion (4%) as a very effective and safe pediculicide for pediculosis control. "
01/01/2013 - "After 7 days of treatment with dimeticone 4%, 7/23 (30.4%) positive children still had lice infestation, with a cure rate of 69.6% (16/23). "
01/01/2013 - "Efficacy and Safety of Dimeticone in the Treatment of Lice Infestation through Prophylaxis of Classmates."
01/01/2008 - "The present study provides the first convincing explanation of the mode of action of the medical device NYDA, a special dimeticone (CAS 9006-65-9) formula containing 92% of two dimeticones with different viscosities specifically designed for the physical treatment of head lice infestations (pediculosis capitis) by suffocation. "
01/01/2020 - "Our main results can be summarized as follows: (i) early detection is crucial for quick and efficient eradication of lice infestations; (ii) dimeticone-based products applied every 4 days effectively remove lice in at most three applications even in case of severe infestations and (iii) minimization of the reinfection risk, e.g. "

05/01/2009 - "The current 12-week study aimed to compare the efficacy of a clindamycin 1%-BPO 5% topical gel with the hydrating excipients dimethicone and glycerin (C/BPO HE) and a clindamycin 1%-BPO 5% topical gel that does not contain hydrating excipients (C/BPO) applied once daily for the treatment of 20 participants with facial acne vulgaris and to determine if there were differences in product preference and participant acceptability between the treatments. "
10/01/2008 - "Forty-six women with mild to moderate facial acne were enrolled in a 3-center, institutional review board-approved, 2-week, split-face study to compare an optimized vehicle (glycerin and dimethicone) clindamycin-BPO formulation with a traditional clindamycin-BPO formulation, with tretinoin cream 0.025% applied to the entire face. "

01/01/2014 - "Seven days after treatment, signs of local skin inflammation had significantly decreased in the dimeticone group (p<0.001). "
10/01/1986 - "The inclusion of dimethicone in the antacid gel preparation did not confer any benefit in terms of symptomatic assessment but did confer a small advantage with regard to objective markers of oesophageal inflammation, suggesting that a dimethicone-containing antacid is of value in the treatment of symptomatic gastro-oesophageal reflux."
09/01/1990 - "Dimethicone/antacid but not alginate/antacid, produced a significant improvement in oesophagitis, oesophageal ulceration and histological grade of inflammation over the 8-week treatment period so that 14 patients treated with dimethicone/antacid and 10 with alginate/antacid had normal endoscopic oesophageal appearances at the end of the study. "

09/01/2000 - "To determine if hand dermatitis, primarily of an occupational nature, could be improved by the use of a protective foam containing dimethicone and glycerin. "
11/01/2011 - "A 3-in-1 perineal care washcloth impregnated with dimethicone 3% versus water and pH neutral soap to prevent and treat incontinence-associated dermatitis: a randomized, controlled clinical trial."
01/01/1984 - "A double-blind trial was carried out in 62 infants with moderate to severe napkin dermatitis to assess the effectiveness and acceptability of topical treatment with a miconazole/hydrocortisone preparation compared with that of a nystatin/benzalkonium chloride/dimethicone/hydrocortisone preparation. "