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1,2,3,4,8,9,10,10a- octahydro- 7bH- cyclopenta(b)(1,4)diazepino(6,7,1hj)indole

has anorectic activity; structure in first source

Also Known As:

WAY 163909; WAY-163909; WAY163909

Networked: 6 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azepines: 11
    - 1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta(b)(1,4)diazepino(6,7,1hj)indole: 6
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - 1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta(b)(1,4)diazepino(6,7,1hj)indole: 6

Experts

1.	Marquis, Karen L: 4 articles (05/2009 - 11/2006)
2.	Rosenzweig-Lipson, Sharon: 4 articles (05/2009 - 11/2006)
3.	Stack, Gary: 3 articles (05/2009 - 01/2007)
4.	Grauer, Steven M: 2 articles (05/2009 - 01/2007)
5.	Logue, Sheree F: 2 articles (05/2009 - 01/2007)
6.	Barrett, James E: 2 articles (06/2007 - 01/2007)
7.	Dunlop, John: 2 articles (06/2007 - 11/2006)
8.	Anastasio, Noelle C: 1 article (01/2018)
9.	Cunningham, Kathryn A: 1 article (01/2018)
10.	Hommel, Jonathan D: 1 article (01/2018)

Related Diseases

1.	Obesity 03/25/2023 - "A reduction of 5.5% (p < 0.05) in body weight was registered in the rat group with diabetes and obesity and 2.56% in the control group with a daily application of WAY-163909 (1 mg/kg) at the end of the study. " 11/01/2006 - "Consistent with a potential therapeutic utility in obesity, schizophrenia and depression WAY-163909 was found to have robust dose-dependent effects in animal models of obesity, psychotic-like behavior or depression."
2.	Polydipsia 06/01/2007 - "The present studies were conducted to evaluate the effects of the novel 5-HT2C receptor agonist WAY-163909 in animal models of antidepressant activity (forced swim test (FST), resident-intruder, olfactory bulbectomy (BULB)), in a schedule-induced polydipsia (SIP) model of obsessive-compulsive disorder and in a model for evaluating sexual dysfunction. "
3.	Obsessive-Compulsive Disorder (Disorder, Obsessive-Compulsive) 06/01/2007 - "The present studies were conducted to evaluate the effects of the novel 5-HT2C receptor agonist WAY-163909 in animal models of antidepressant activity (forced swim test (FST), resident-intruder, olfactory bulbectomy (BULB)), in a schedule-induced polydipsia (SIP) model of obsessive-compulsive disorder and in a model for evaluating sexual dysfunction. "
4.	Bulimia (Binge Eating) 01/01/2018 - "This study assessed the effects of 5-HT2CR activation via the selective 5-HT2CR agonist WAY163909 on binge eating-related behaviors in adult male Sprague-Dawley rats. "
5.	Body Weight (Weight, Body) 03/25/2023 - "A reduction of 5.5% (p < 0.05) in body weight was registered in the rat group with diabetes and obesity and 2.56% in the control group with a daily application of WAY-163909 (1 mg/kg) at the end of the study. " 03/25/2023 - "In our study, using WAY-163909 (1 mg/kg) led to a reduction of blood glucose levels, immunoreactive insulin, and body weight." 03/25/2023 - "We investigated the effect of WAY-163909, a novel 5-hydroxytryptamine selective 2C receptor agonist on body weight, blood glucose levels, and insulin resistance in obese and diabetic Wistar rats. "

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