|1.||Marquis, Karen L: 4 articles (05/2009 - 11/2006)|
|2.||Rosenzweig-Lipson, Sharon: 4 articles (05/2009 - 11/2006)|
|3.||Stack, Gary: 3 articles (05/2009 - 01/2007)|
|4.||Grauer, Steven M: 2 articles (05/2009 - 01/2007)|
|5.||Logue, Sheree F: 2 articles (05/2009 - 01/2007)|
|6.||Barrett, James E: 2 articles (06/2007 - 01/2007)|
|7.||Dunlop, John: 2 articles (06/2007 - 11/2006)|
|8.||Liu, Zhi: 1 article (05/2009)|
|9.||Graf, Radka: 1 article (05/2009)|
|10.||Huselton, Christine: 1 article (05/2009)|
|1.||Obsessive-Compulsive Disorder (Disorder, Obsessive-Compulsive)
06/01/2007 - "The present studies were conducted to evaluate the effects of the novel 5-HT2C receptor agonist WAY-163909 in animal models of antidepressant activity (forced swim test (FST), resident-intruder, olfactory bulbectomy (BULB)), in a schedule-induced polydipsia (SIP) model of obsessive-compulsive disorder and in a model for evaluating sexual dysfunction. "
|2.||Schizophrenia (Dementia Praecox)
11/01/2006 - "Consistent with a potential therapeutic utility in obesity, schizophrenia and depression WAY-163909 was found to have robust dose-dependent effects in animal models of obesity, psychotic-like behavior or depression."
01/01/2007 - "As antipsychotic efficacy is proposed to be associated with decreased mesolimbic DA neurotransmission by virtue of DA D2 receptor antagonism, the 5-HT2C-selective receptor agonist, WAY-163909 [(7bR,10aR)-1,2, 3,4,8,9,10,10a-octahydro-7bH-cyclopenta-[b][1,4]diazepino[6,7, 1hi]indole], was evaluated in animal models of schizophrenia and in vivo microdialysis and electrophysiology to determine the effects on mesolimbic and nigrostriatal DA neurotransmission. "
01/01/2007 - "Similar to clozapine, WAY-163909 (1.7-30 mg/kg i.p.) decreased apomorphine-induced climbing with little effect on stereotypy and no significant induction of catalepsy. "
05/01/2009 - "In mice, co-administration of either haloperidol, or clozapine, produced a significant leftward shift in the ability of WAY-163909 to block apomorphine-induced climbing behavior, without any affect on apomorphine-induced stereotypy or an increased propensity for catalepsy. "
|1.||5-HT2C Serotonin Receptor