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thiaplidiaquinone B

a meroterpenoid with antineoplastic activity from Aplidium conicum; structure in first source

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - thiaplidiaquinone B: 1

Experts

1.	Barker, David: 1 article (08/2015)
2.	Bourguet-Kondracki, Marie-Lise: 1 article (08/2015)
3.	Copp, Brent R: 1 article (08/2015)
4.	Dubois, Joëlle: 1 article (08/2015)
5.	Harper, Jacquie L: 1 article (08/2015)
6.	Khalil, Iman M: 1 article (08/2015)
7.	Shaw, Lisa: 1 article (08/2015)
8.	Valentin, Alexis: 1 article (08/2015)

Related Diseases

1.

08/10/2015 - "Intriguingly, and in contrast to previous reports, the mechanism of Jurkat cell death (necrosis vs. apoptosis) was found to be dependent upon the positioning of one of the geranyl sidechains in the compounds with thiaplidiaquinone A and its dioxothiazine regioisomer causing death dominantly by necrosis, while thiaplidiaquinone B and its dioxothiazine isomer caused cell death via apoptosis. "

Related Drugs and Biologics

1.	thiaplidiaquinone A