arvelexin

a phytoalexin; structure in first source

Networked: 2 relevant articles (1 outcomes, 1 trials/studies)

1.	Colitis 08/01/2012 - "In the DSS-induced colitis model, arvelexin significantly reduced the severity of colitis, as assessed by disease activity, colonic damage, neutrophil infiltration, and levels of colonic iNOS. " 08/01/2012 - "These results demonstrate that the ameliorative effects of arvelexin on colonic injury are mainly related to its ability to inhibit the inflammatory responses via NF-κB inactivation, and support its possible therapeutic role in colitis. " 08/01/2012 - "In the present study, the effects of arvelexin were investigated in a dextran sulfate sodium (DSS)-induced colitis mouse model and in a cellular model. " 01/25/2023 - "Although we have previously reported the anti-inflammatory effects of 7-hydroxyl-1-methylindole-3-acetonitrile (7-HMIA), a synthesized analog of arvelexin on macrophages and paw edema, its anti-colitis effect and its mechanism are not known. "
2.	Inflammation (Inflammations) 08/01/2012 - "Arvelexin inhibits colonic inflammation by suppression of NF-κB activation in dextran sulfate sodium-induced mice and TNF-α-induced colonic epithelial cells."
3.	Edema (Dropsy) 01/25/2023 - "Although we have previously reported the anti-inflammatory effects of 7-hydroxyl-1-methylindole-3-acetonitrile (7-HMIA), a synthesized analog of arvelexin on macrophages and paw edema, its anti-colitis effect and its mechanism are not known. "

1.	Dextran Sulfate
2.	7-hydroxyl-1-methylindole-3-acetonitrile