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GW8510

3' substituted indolone as a scaffold for the development of neuroprotective drug; structure in first source

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - GW8510: 6

Experts

1.	Chen, Chen-Guo: 2 articles (01/2020 - 01/2018)
2.	Li, Jian: 2 articles (01/2020 - 01/2018)
3.	Shu, Yang: 2 articles (01/2020 - 01/2018)
4.	Zhao, Xiao-Hui: 2 articles (01/2020 - 01/2018)
5.	Ak, Handan: 1 article (10/2021)
6.	Atay, Sevcan: 1 article (10/2021)
7.	Aydin, Hikmet Hakan: 1 article (10/2021)
8.	Rüstem, Duygu Gençalp: 1 article (10/2021)
9.	Li, Mei-Yu: 1 article (01/2020)
10.	Li, Xiao-Qin: 1 article (01/2020)

Related Diseases

1.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2016 - "Repositioning of a cyclin-dependent kinase inhibitor GW8510 as a ribonucleotide reductase M2 inhibitor to treat human colorectal cancer."
2.	Parkinson Disease (Parkinson's Disease) 01/01/2016 - "GW8510 demonstrated neuroprotective ability in MN9D cells in the presence of 1-methyl-4-phenylpyridium (MPP(+)), a widely used neurotoxin model for Parkinson's disease. " 01/01/2016 - "Gene Expression-Based Screen for Parkinson's Disease Identifies GW8510 as a Neuroprotective Agent."
3.	Pancreatic Neoplasms (Pancreatic Cancer) 10/28/2021 - "Targeting RRM2 using GW8510 may have the potential to increase gemcitabine sensitivity in pancreatic cancer." 10/28/2021 - "Synergistic Interactions between GW8510 and Gemcitabine in an In Vitro Model of Pancreatic Cancer."
4.	Neoplasms (Cancer) 01/01/2020 - "Furthermore, combination of tamoxifen and GW8510 resulted in marked growth inhibition of tamoxifen-resistant BBC xenograft tumor in vivo compared to tamoxifen or GW8510 alone. "
5.	Lung Neoplasms (Lung Cancer) 02/01/2006 - "We treated the cells with GW8510 at concentrations of 0-10 microM, and found that it suppressed cell growth in vitro in all the lung cancer cells but not in NHFB. " 02/01/2006 - "In order to evaluate the antitumor activity of one such inhibitor, GW8510, against human lung cancers, we analyzed the effects of GW8510 on six nonsmall cell lung cancer (NSCLC) cell lines (A549, H1299, H460, H226, H358 and H322) and normal human fibroblast (NHFB). "

Related Drugs and Biologics

1.	Cyclin-Dependent Kinases (cdk Proteins)
2.	Gemcitabine
3.	ribonucleotide reductase M2
4.	Neuroprotective Agents
5.	Tamoxifen
6.	Neurotoxins
7.	crotalid hemorrhagic factor B (NHFb)