asialoerythropoietin

protects against neonatal hypoxia-ischemia

Also Known As:

asialoEPO

Networked: 17 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Glycoconjugates: 1353
  - Glycoproteins: 24834
    - Colony-Stimulating Factors: 1599
      - Erythropoietin: 12227
        asialoerythropoietin: 17
    - Asialoglycoproteins: 57
      - asialoerythropoietin: 17
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intercellular Signaling Peptides and Proteins: 29768
    - Cytokines: 164289
      - Hematopoietic Cell Growth Factors: 13
        Colony-Stimulating Factors: 1599
        Erythropoietin: 12227
        asialoerythropoietin: 17
  - Glycoproteins: 24834
    - Colony-Stimulating Factors: 1599
      - Erythropoietin: 12227
        asialoerythropoietin: 17
    - Asialoglycoproteins: 57
      - asialoerythropoietin: 17
- Peptides: 82426
  - Intercellular Signaling Peptides and Proteins: 29768
    - Cytokines: 164289
      - Hematopoietic Cell Growth Factors: 13
        Colony-Stimulating Factors: 1599
        Erythropoietin: 12227
        asialoerythropoietin: 17
Biological Factors: 2472
- Intercellular Signaling Peptides and Proteins: 29768
  - Cytokines: 164289
    - Hematopoietic Cell Growth Factors: 13
      - Colony-Stimulating Factors: 1599
        Erythropoietin: 12227
        asialoerythropoietin: 17

Experts

1.	Kubota, Keiichi: 3 articles (04/2008 - 08/2007)
2.	Sawada, Tokihiko: 3 articles (04/2008 - 08/2007)
3.	Leist, Marcel: 3 articles (11/2004 - 05/2003)
4.	Fujiwara, Hisayoshi: 2 articles (03/2012 - 11/2010)
5.	Fujiwara, Takako: 2 articles (03/2012 - 11/2010)
6.	Goto, Kazuko: 2 articles (03/2012 - 11/2010)
7.	Kanamori, Hiromitsu: 2 articles (03/2012 - 11/2010)
8.	Kawaguchi, Tomonori: 2 articles (03/2012 - 11/2010)
9.	Kawasaki, Masanori: 2 articles (03/2012 - 11/2010)
10.	Maruyama, Rumi: 2 articles (03/2012 - 11/2010)

Related Diseases

1.	Acute Lung Injury 11/01/2014 - "Asialoerythropoietin ameliorates bleomycin-induced acute lung injury in rabbits by reducing inflammation." 11/01/2014 - "In the present study, a rabbit model of bleomycin-induced acute lung injury was established to examine the effects of asialoerythropoietin (AEP), an agent with tissue-protective activities, on pulmonary inflammation. "
2.	Inflammation (Inflammations) 03/01/2012 - "AsialoEPO treatment for 4 weeks significantly mitigated progression of the dysfunction and remodeling and reduced myocardial fibrosis, inflammation, and oxidative damage. " 11/01/2014 - "Asialoerythropoietin ameliorates bleomycin-induced acute lung injury in rabbits by reducing inflammation." 03/01/2012 - "In addition, the asialoEPO-treated heart showed less myocardial fibrosis, inflammation, and oxidative damage, and diminished atrophic cardiomyocyte degeneration, which was accompanied by restored expression of GATA-4 and sarcomeric proteins. "
3.	Anemia 11/30/2010 - "Although only rhEPO relieved the nephrectomy-induced anemia, both rhEPO and asialoEPO significantly and similarly mitigated left ventricular dilation and dysfunction. "
4.	Reperfusion Injury 02/01/2010 - "They were divided into four group: (i) non-diabetic plus ischaemia-reperfusion injury; (ii) non-diabetic plus ischaemia-reperfusion injury plus asialoerythropoietin (3000 IU/kg bodyweight); (iii) diabetic plus ischaemia-reperfusion injury; and (iv) diabetic plus ischemia-reperfusion injury plus asialoerythropoietin. " 08/27/2007 - "Asialoerythropoietin has strong renoprotective effects against ischemia-reperfusion injury in a murine model." 08/27/2007 - "The renoprotective effect of erythropoietin (EPO) and the nonhematopoietic EPO, asialoEPO was investigated in a murine ischemia-reperfusion injury (I/R) model. " 02/01/2010 - "The aim of the present study was to clarify the mechanism of diabetes-related acceleration of renal damage after ischaemia-reperfusion injury and to examine the therapeutic potential of asialoerythropoietin, a non-haematopoietic erythropoietin derivative, against ischaemia-reperfusion-induced acute kidney injury in diabetic mice. "
5.	Acute Kidney Injury (Acute Renal Failure) 02/01/2010 - "Renoprotective effects of asialoerythropoietin in diabetic mice against ischaemia-reperfusion-induced acute kidney injury." 02/01/2010 - "The renoprotective effects of asialoerythropoietin on acute kidney injury may be mediated through the induction of bcl-2 and BMP-7." 02/01/2010 - "The aim of the present study was to clarify the mechanism of diabetes-related acceleration of renal damage after ischaemia-reperfusion injury and to examine the therapeutic potential of asialoerythropoietin, a non-haematopoietic erythropoietin derivative, against ischaemia-reperfusion-induced acute kidney injury in diabetic mice. "

Related Drugs and Biologics

1.	Bleomycin (Blenoxane)
2.	Erythropoietin
3.	asialoerythropoietin
4.	Bone Morphogenetic Protein 7
5.	Sarcoglycans (beta Sarcoglycan)
6.	Intercellular Signaling Peptides and Proteins (Growth Factors)
7.	N-Acetylneuraminic Acid (Sialic Acid)
8.	Neuroprotective Agents
9.	Monocrotaline
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Nephrectomy
2.	Catheters
3.	Intravenous Injections
4.	Intra-Arterial Injections