|1.||Piomelli, Daniele: 8 articles (01/2011 - 02/2006)|
|2.||Hasanein, Parisa: 5 articles (02/2016 - 09/2008)|
|3.||Lutz, Beat: 5 articles (01/2015 - 08/2008)|
|4.||Duranti, Andrea: 5 articles (01/2011 - 07/2007)|
|5.||Cravatt, Benjamin F: 4 articles (10/2015 - 05/2007)|
|6.||Parker, Linda A: 4 articles (10/2015 - 02/2007)|
|7.||Lichtman, Aron H: 4 articles (04/2014 - 05/2007)|
|8.||Di Marzo, Vincenzo: 4 articles (01/2013 - 09/2005)|
|9.||Tontini, Andrea: 4 articles (09/2009 - 07/2007)|
|10.||Limebeer, Cheryl L: 3 articles (10/2015 - 02/2008)|
01/01/2013 - "We investigated the effect of high doses of intrathecal URB597 on allodynia and hyperalgesia in rats with chronic constriction injury (CCI) of the sciatic nerve. "
10/01/2012 - "Single, but not repeated, URB597 treatment significantly attenuated the development of inflammatory hyperalgesia (P < 0.001, vs. vehicle-treated animals). "
05/16/2012 - "Intraplantar injection of AEA (10 μg/10 μl) or URB597 (9 μg/10 μl) transiently attenuated hyperalgesia through activation of peripheral CB₁ receptors. "
09/01/2009 - "Acute administration of the irreversible FAAH inhibitor, cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester (URB597), or the reversible FAAH inhibitor, 1-oxo-1-[5-(2-pyridyl)-2-yl]-7-phenylheptane (OL-135), decreased allodynia in both tests. "
06/01/2009 - "URB597 (0.3 and 0.5 mg/kg) reversed chemical and thermal hyperalgesia in diabetic rats. "
|2.||Neuralgia (Stump Neuralgia)
01/01/2013 - "Yet, intrathecal URB597 is only partially effective at counteracting neuropathic pain. "
07/01/2007 - "In the present study, we investigated the effects of the selective FAAH inhibitor URB597 (KDS-4103, cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester) in the mouse chronic constriction injury (CCI) model of neuropathic pain. "
02/01/2014 - "Several recent studies examining the contribution of CB₁ and/or CB₂ receptors on the peripheral antinociceptive effects of AEA, 2-AG, URB597 and URB602 in neuropathic pain conditions using either pharmacological tools or transgenic mice separately have been reported, but the exact mechanism is still uncertain. "
07/01/2012 - "The administration of ST4070 generated long-lasting neuropathic pain relief compared with pregabalin and the FAAH inhibitors OL135 and URB597. "
11/01/2008 - "However, the anti-nociceptive effects of the combination of peripherally injected 2-AG, URB602 and URB597 in a neuropathic pain model have not yet been determined. "
04/01/2014 - "These results suggest that URB597 produces antinociception in these models of 'pain stimulated' and 'pain depressed' behavior, but with different rates of onset and differential involvement of CBRs. "
04/01/2014 - "Consistent with FAAH inhibitor effects in other assays of pain-stimulated behavior, URB597 (1-10 mg/kg intraperitoneally) produced dose-related and CB1R-mediated decreases in acid-stimulated stretching. "
05/01/2011 - "Local injection of URB597 into OA knee joints reduces mechanonociception and pain, and this response is mediated by CB(1) receptors. "
06/01/2009 - "Administration of URB597 at a dose of 0.1 mg/kg did not alter pain-related behaviors in control and diabetic groups compared with those of the respective control groups. "
02/01/2006 - "Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models."
01/01/2014 - "URB597 decreased leukocyte rolling and adhesion, as well as inflammation-induced hyperaemia. "
12/01/2008 - "URB597 inhibited receptive field expansions but not mechanically evoked responses of spinal neurons in rats with hind paw inflammation. "
01/01/2014 - "The present study examined whether URB597, a potent and selective FAAH inhibitor, could alter inflammation and pain in a mouse model of acute synovitis. "
08/01/2008 - "Inflammation was significantly reduced in the presence of URB597, VDM11, or both as evaluated by macroscopic damage score, myeloperoxidase levels, and colon length. "
10/01/2005 - "In conclusion, the results show that in mice, treatment with indomethacin and URB597 produce SR144528-sensitive anti-inflammatory effects in the carrageenan model of acute inflammation."
05/01/2013 - "On the contrary, URB-597 (1 mg/kg) had an anti-convulsive effect, as it increased the threshold for the occurrence of minimal seizures and reduced EEG epileptiform activity. "
07/01/2011 - "In contrast, URB597 did not affect the development of seizures in the kindling paradigm. "
08/01/2015 - "The FAAH inhibitor, URB597, reduced cocaine-induced seizures and epileptiform electroencephalographic activity. "
01/01/2015 - "URB597 (1.0 mg/kg) abolished cocaine-induced seizure, yet it did not protect against acute liver injury. "
03/01/2015 - "AM404 and URB597 significantly alleviated kainic acid-induced SE, decreasing behavioral manifestations, duration of seizure events and SE in general without changing the amplitude of local field potentials. "
|1.||fatty-acid amide hydrolase (fatty acid amide hydrolase)
|7.||Lipase (Acid Lipase)
|9.||Serotonin (5 Hydroxytryptamine)