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BVT.12777

aminoguanidine carboxylate that activates ATP-sensitive K+ channels; structure in first source

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amidines: 14
  - Guanidines: 29
    - BVT.12777: 1

Experts

1.	Ashford, Michael L J: 1 article (08/2004)
2.	Harvey, Jenni: 1 article (08/2004)
3.	Kinsella, Jackie M: 1 article (08/2004)
4.	Laidlaw, Hilary A: 1 article (08/2004)
5.	Sutherland, Calum: 1 article (08/2004)
6.	Tang, Teresa: 1 article (08/2004)

Related Diseases

1.

08/24/2004 - "BVT.12777 hyperpolarized CRI-G1 rat insulinoma cells by activation of KATP channels. "
08/24/2004 - "This study shows that BVT.12777, like leptin, activates KATP channels in insulinoma cells. "
08/24/2004 - "The aminoguanidine carboxylate BVT.12777 activates ATP-sensitive K+ channels in the rat insulinoma cell line, CRI-G1."
08/24/2004 - "We have assessed whether one of these analogues, the aminoguanidine carboxylate BVT.12777, opens KATP channels in rat insulinoma cells, by the same mechanism as leptin. "

Related Drugs and Biologics

1.	KATP Channels
2.	Leptin
3.	Adenosine Triphosphate (ATP)
4.	pimagedine (aminoguanidine)