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bacoside A

from Bacopa monnieri; structure in first source

Networked: 25 relevant articles (2 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Glycosides: 2119
  - Saponins: 2867
    - bacoside A: 25
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Triterpenes: 2493
      - bacoside A: 25

Experts

1.	Mathew, Jobin: 6 articles (02/2012 - 04/2010)
2.	Paulose, C S: 5 articles (02/2012 - 04/2010)
3.	Janani, Panneerselvam: 3 articles (05/2010 - 10/2009)
4.	Parthasarathy, Chandrakesan: 3 articles (05/2010 - 10/2009)
5.	Sivakumari, Kanakarajan: 3 articles (05/2010 - 10/2009)
6.	Nandhu, M S: 2 articles (09/2010 - 07/2010)
7.	Paul, Jes: 2 articles (09/2010 - 07/2010)
8.	Geetha, Arumugam: 2 articles (05/2010 - 03/2010)
9.	Arockiasamy, Sumathy: 1 article (01/2021)
10.	Jonnalagadda, Bhavana: 1 article (01/2021)

Related Diseases

1.	Wounds and Injuries (Trauma) 08/01/2010 - "The tensile strength of the incision wound was increased (538.47 +/- 0.14 g) in the Bacoside-A treated group. " 08/01/2010 - "Bacoside-A was screened for wound healing activity by excision, incision and dead space wound on Swiss albino rats. " 08/01/2010 - "The wound healing activity of Bacoside-A was more effective in various wound models compared to the standard skin ointment Nitrofurazone." 08/01/2010 - "The SDS-PAGE caseinolytic zymogram analysis of inhibition of matrix metalloproteases (MMPs) enzyme from the excision wound by Bacoside-A, an isolated constituent, was done with the concentrations 100 and 200 micromg/ml. In Bacoside-A treated groups, epithelialization of the excision wound was faster with a high rate (18.30 +/- 0.01 days) of wound contraction. "
2.	Demyelinating Diseases (Demyelinating Disease) 01/01/2019 - "Histopathological analysis revealed that the Bacoside-A treated mice at a dose of 10 mg/kg exhibited a significant reduction in cellular infiltrations, cellular changes, and demyelination in cerebral tissues, but unable to protect at a higher dose in both models. "
3.	Neoplasms (Cancer) 01/01/2017 - "Bacoside A Induces Tumor Cell Death in Human Glioblastoma Cell Lines through Catastrophic Macropinocytosis." 10/02/2023 - "Bacoside A (gypenoside, Gyp) is a potent bioactive compound derived from Gynostemma pentaphyllum, known to exert inhibitory effects on various malignant tumors. " 01/01/2021 - "The quantitative estimation of bacosides enriched standard extract of Bacopa monnieri by HPTLC showed 59.38% of Bacoside A and various active compounds with anti-oxidant, anti-cancer, anti-microbial, anti-inflammatory properties were also analyzed by GC-MS analysis. " 01/01/2017 - "In this study, we show that the extracts of an Indian traditional medicinal plant Bacopa monnieri (BM) and its bioactive component Bacoside A can generate dosage associated tumor specific disturbances in the hydrostatic pressure balance of the cell via a mechanism involving excessive phosphorylation of calcium/calmodulin-dependent protein kinase IIA (CaMKIIA/CaMK2A) enzyme that is further involved in the release of calcium from the smooth endoplasmic reticular networks. "
4.	Memory Disorders (Memory Loss) 04/01/2010 - "monnieri and bacoside A prevents the occurrence of seizures thereby reducing the impairment of GABAergic activity, motor learning, and memory deficit." 07/20/2010 - "In the present study, effect of Bacopa monnieri (L.) Pennel and its active component bacoside-A on spatial recognition memory deficit and alterations of GABA receptor in the striatum of epileptic rats were investigated. " 07/20/2010 - "Decreased GABA receptor in the striatum and spatial recognition memory deficit in epileptic rats: effect of Bacopa monnieri and bacoside-A." 01/01/2018 - "Effect of traditional medicine brahmi vati and bacoside A-rich fraction of Bacopa monnieri on acute pentylenetetrzole-induced seizures, amphetamine-induced model of schizophrenia, and scopolamine-induced memory loss in laboratory animals."
5.	Osteoporosis 01/01/2021 - "This result is indicating that bacoside-A may be useful for osteoporosis treatments." 01/01/2021 - "The present study suggest that bacoside-A will be applied to ameliorate the process of osteogenesis in hBMSCs to repair damaged bone structure during MSC-based therapy; this will be an excellent and auspicious treatment for bone-associated disorders including osteoporosis. "

Related Drugs and Biologics

1.	Ointments (Pastes)
2.	Nitrofurazone (Nitrofural)
3.	GABA Receptors (GABA Receptor)
4.	Enzymes
5.	Calcium-Calmodulin-Dependent Protein Kinases
6.	Calcium
7.	Matrix Metalloproteinases (MMPs)
8.	Antioxidants
9.	Metalloproteases (Metalloproteinases)
10.	Chemokines

Related Therapies and Procedures

1.	Therapeutics
2.	Chemoprevention
3.	Traditional Medicine (Folk Remedies)
4.	Ligation