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isoliensinine

isolated from the Chinese herbal medicine lotus plumule; structure in first source

Networked: 20 relevant articles (2 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Isoquinolines: 34
      - isoliensinine: 20

Experts

1.	Shu, Guangwen: 3 articles (08/2017 - 10/2015)
2.	Yang, Xinzhou: 3 articles (08/2017 - 10/2015)
3.	Manogaran, Prasath: 2 articles (03/2022 - 10/2019)
4.	Cheng, Lin: 2 articles (01/2022 - 01/2021)
5.	Cheng, Yan: 2 articles (01/2022 - 01/2021)
6.	Gao, Li-Chen: 2 articles (01/2022 - 01/2021)
7.	Li, Hong-Li: 2 articles (01/2022 - 01/2021)
8.	Long, Hui-Zhi: 2 articles (01/2022 - 01/2021)
9.	Luo, Hong-Yu: 2 articles (01/2022 - 01/2021)
10.	Wen, Dan-Dan: 2 articles (01/2022 - 01/2021)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 10/01/2022 - "PRACTICAL APPLICATIONS: This study highlighted the protective effects and mechanisms of three main active ingredients (Liensinine, Isoliensinine, and Neferine) in the lotus embryo on a typical cell model of Alzheimer's disease (AD). " 01/01/2021 - "Isoliensinine, a bisbenzylisoquinoline alkaloid isolated from Nelumbo nucifera Gaertn, exerts a variety of beneficial effects, such as antitumor, cardioprotective, antioxidant, antidepressant, and anti-HIV effects, and ameliorates T2DM with hyperlipidemia and Alzheimer's disease. "
2.	Hyperlipidemias (Hyperlipidemia) 01/01/2021 - "Isoliensinine, a bisbenzylisoquinoline alkaloid isolated from Nelumbo nucifera Gaertn, exerts a variety of beneficial effects, such as antitumor, cardioprotective, antioxidant, antidepressant, and anti-HIV effects, and ameliorates T2DM with hyperlipidemia and Alzheimer's disease. "
3.	Hepatocellular Carcinoma (Hepatoma) 06/28/2016 - "Our previous study discovered that isoliensinine (isolie) triggers hepatocellular carcinoma (HCC) cell apoptosis via inducing p65 dephosphorylation at Ser536 and inhibition of NF-κB. " 06/28/2016 - "Isoliensinine induces dephosphorylation of NF-kB p65 subunit at Ser536 via a PP2A-dependent mechanism in hepatocellular carcinoma cells: roles of impairing PP2A/I2PP2A interaction." 10/14/2015 - "Isoliensinine, a Bioactive Alkaloid Derived from Embryos of Nelumbo nucifera, Induces Hepatocellular Carcinoma Cell Apoptosis through Suppression of NF-κB Signaling."
4.	Triple Negative Breast Neoplasms 07/29/2015 - "Further studies showed that isoliensinine could significantly increase the production of reactive oxygen species (ROS) in triple-negative breast cancer cells, but not in MCF-10A cells. " 07/29/2015 - "Here, we explored the effects of these alkaloids on triple-negative breast cancer cells and found that among the three alkaloids isoliensinine possesses the most potent cytotoxic effect, primarily by inducing apoptosis. "
5.	Dyslipidemias (Dyslipidemia) 08/23/2017 - "This study was designed to explore the effects and mechanism of isoliensinine (isolie) from embryos of Nelumbo nucifera on type 2 diabetes and dyslipidemia in vivo and in vitro. "

Related Drugs and Biologics

1.	Alkaloids
2.	neferine
3.	liensinine
4.	Benzylisoquinolines
5.	Antioxidants
6.	Antidepressive Agents (Antidepressants)
7.	isoquinoline
8.	Reactive Oxygen Species (Oxygen Radicals)
9.	RNA (Ribonucleic Acid)
10.	Cisplatin (Platino)

Related Therapies and Procedures

1.	Chinese Traditional Medicine (Traditional Chinese Medicine)