LY368052

04/01/2005 - "Baroreflex sensitivity was significantly depressed in heart failure and restored completely by acute treatment with LY-368052. "
04/01/2005 - "Dogs were chronically instrumented, and heart failure was induced by right ventricular pacing at 240 beats/min for 3-4 wk. LY-368052 dose-dependently increased left ventricular contractile performance before and after the development of CHF to a similar extent. "
04/01/2005 - "We also examined the effect of LY-368052 on baroreflex sensitivity and the efferent neural mechanisms of the bradycardic response in heart failure. "
04/01/2005 - "We compared the cardiac inotropic, lusitropic, and chronotropic responses to the Na(+) channel enhancer LY-368052 in conscious dogs before and after development of congestive heart failure (CHF). "
04/01/2005 - "LY-368052 improved cardiac relaxation and induced bradycardia in dogs with heart failure but not in normal dogs. "

04/01/2005 - "LY-368052 improved cardiac relaxation and induced bradycardia in dogs with heart failure but not in normal dogs. "
04/01/2005 - "The negative chronotropic effect of LY-368052 was eliminated by ganglionic blockade but not beta-adrenergic blockade, suggesting that the bradycardia was mediated by the autonomic nervous system via enhanced parasympathetic tone. "