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873140 compound

a spiro-diketo-piperazine; a potent noncompetitive allosteric antagonist of the CCR5 receptor with concomitantly potent antiviral effects for HIV-1; structure in first source
Also Known As:
4-((4-(((3R)-1-butyl-3-((R)-cyclohexyl(hydroxy)methyl)-2,5-dioxo-1,4,9-triazaspiro(5.5)undec-9-yl)methyl)phenyl)oxy)benzoic acid hydrochloride; APL compound; GW873140; aplaviroc
Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Nakata, Hirotomo: 2 articles (06/2008 - 02/2005)
2. Takaoka, Yoshikazu: 2 articles (06/2008 - 02/2005)
3. Mitsuya, Hiroaki: 2 articles (06/2008 - 02/2005)
4. Maeda, Kenji: 2 articles (06/2008 - 02/2005)
5. Tamamura, Hirokazu: 1 article (06/2008)
6. Steinberg, Seth M: 1 article (06/2008)
7. Fujii, Nobutaka: 1 article (06/2008)
8. Koh, Yasuhiro: 1 article (06/2008)
9. Bredeek, U Fritz: 1 article (10/2007)
10. Harbour, Michael J: 1 article (10/2007)

Related Diseases

1. HIV Infections (HIV Infection)
2. Infection
3. Acquired Immunodeficiency Syndrome (AIDS)

Related Drugs and Biologics

1. maraviroc
2. 1- ((4,6- dimethyl- 5- pyrimidinyl)carbonyl)- 4- (4- (2- methoxy- 4- (trifluoromethyl)phenyl)ethyl- 3- methyl- 1- piperazinyl)- 4- methylpiperidine (vicriviroc)
3. Carbon Monoxide
4. Interleukin Receptor Common gamma Subunit
5. RNA (Ribonucleic Acid)
6. ONO 4128
7. 4-((4-((3R)-1-butyl-3-((1R)) cyclohexylhy- droxymethyl)- 2,5- dioxo- 1,4,9- triazaspiro(5.5)undec- 9- yl methyl)phenoxy)benzoic acid hydrochloride