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9- deoxy- 9- chloro- 15- deoxy- 16- hydroxy- 17,17- trimethylene- 19,20- didehydroprostaglandin E2

an EP(4) receptor agonist

Also Known As:

(16S)-9-deoxy-9beta-chloro-15-deoxy-16-hydroxy-17,17-trimethylene-19,20-didehydro-PGE(2) sodium salt; ONO AE1-259; ONO-AE1-259

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Lipids: 114793
- Fatty Acids: 27405
  - Unsaturated Fatty Acids: 8236
    - Eicosanoids: 3262
      - Prostaglandins: 17100
        Prostaglandins E: 2673
        Dinoprostone: 10047
        9-deoxy-9-chloro-15-deoxy-16-hydroxy-17,17-trimethylene-19,20-didehydroprostaglandin E2: 3
Biological Factors: 2472
- Inflammation Mediators: 1113
  - Autacoids: 276
    - Eicosanoids: 3262
      - Prostaglandins: 17100
        Prostaglandins E: 2673
        Dinoprostone: 10047
        9-deoxy-9-chloro-15-deoxy-16-hydroxy-17,17-trimethylene-19,20-didehydroprostaglandin E2: 3

Experts

1.	Aoshiba, Kazutetsu: 2 articles (08/2014 - 12/2009)
2.	Nagai, Atsushi: 2 articles (08/2014 - 12/2009)
3.	Tsuji, Takao: 2 articles (08/2014 - 12/2009)
4.	Itoh, Masayuki: 1 article (08/2014)
5.	Kikuchi, Ryota: 1 article (08/2014)
6.	Nakamura, Hiroyuki: 1 article (08/2014)
7.	Yamaguchi, Kazuhiro: 1 article (08/2014)
8.	Yokohori, Naoko: 1 article (12/2009)
9.	Ariumi, Hideto: 1 article (05/2002)
10.	Hirabara, Yasutoshi: 1 article (05/2002)

Related Diseases

1.	Tachycardia (Tachyarrhythmias) 05/10/2002 - "An i.c.v. administration of the EP3 agonist ONO-AE-248 (50.0 nmol) resulted in an increase in RSNA with pressor and tachycardia responses, while administration of the EP2 agonist ONO-AE1-259 and the EP4 agonist ONO-AE1-329 caused transient hypotension and slight increases in HR and RSNA. "
2.	Pulmonary Emphysema 08/01/2014 - "Since angiogenesis is stimulated by PGE2, we examined whether ONO-AE1-259, a selective E-prostanoid (EP) 2 receptor agonist, might promote adipose angiogenesis and adipogenesis in a murine model of elastase-induced pulmonary emphysema (EIE mice). "
3.	Hypotension (Low Blood Pressure) 05/10/2002 - "An i.c.v. administration of the EP3 agonist ONO-AE-248 (50.0 nmol) resulted in an increase in RSNA with pressor and tachycardia responses, while administration of the EP2 agonist ONO-AE1-259 and the EP4 agonist ONO-AE1-329 caused transient hypotension and slight increases in HR and RSNA. "
4.	Emphysema 12/01/2009 - "These results suggest that systemically administered ONO-AE1-259 stimulates pulmonary angiogenesis in an elastase-induced murine model of emphysema."

Related Drugs and Biologics

1.	Pancreatic Elastase (Elastase)
2.	Dinoprostone (PGE2)
3.	Prostaglandins
4.	ONO-AE1-329
5.	ONO AE 248