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deshydroxyfluorocholine

a choline transport tracer; structure in first source

Also Known As:

(18F)dOC; deshydroxy-(18F)fluorocholine

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133

Experts

1.	Hauser, A: 1 article (10/2004)
2.	Henriksen, G: 1 article (10/2004)
3.	Herz, M: 1 article (10/2004)
4.	Schwaiger, M: 1 article (10/2004)
5.	Wester, H-J: 1 article (10/2004)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 10/01/2004 - "In conclusion, [18F]dOC is taken up into AR42J rat pancreatic carcinoma and PC-3 human prostate cancer cells by a choline specific transport system. " 10/01/2004 - "The specificity of uptake of [18F]dOC was compared with that of [11C]choline ([11C]CHO) in cultured rat pancreatic carcinoma and PC-3 human prostate cancer cells in vitro. "
2.	Pancreatic Neoplasms (Pancreatic Cancer) 10/01/2004 - "In conclusion, [18F]dOC is taken up into AR42J rat pancreatic carcinoma and PC-3 human prostate cancer cells by a choline specific transport system. " 10/01/2004 - "The specificity of uptake of [18F]dOC was compared with that of [11C]choline ([11C]CHO) in cultured rat pancreatic carcinoma and PC-3 human prostate cancer cells in vitro. "
3.	Neoplasms (Cancer) 10/01/2004 - "In addition, biodistribution of [18F]dOC and [11C]CHO was compared in AR42J- and PC-3 tumor bearing mice. " 10/01/2004 - "In contrast to [18F]dOC, which is transported but not intracellularly trapped, the choline kinase substrate [11C]CHO is transported into tumor cells and retained. " 10/01/2004 - "Biodistribution data after simultaneous injection of both tracers into AR42J tumor bearing mice revealed slightly higher tumor uptake for [18F]dOC at 10 min post-injection, whereas [11C]CHO uptake was higher at later time points. "

Related Drugs and Biologics

1.	Dihydrotachysterol (AT 10)
2.	Choline Kinase
3.	Choline (Choline Chloride)