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psymberin

from the Indo-Pacific marine sponge Ircinia ramosa; structure in first source

Also Known As:

irciniastatin A

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Coumarins: 826
        psymberin: 6
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Coumarins: 826
        psymberin: 6

Experts

1.	Iwabuchi, Yoshiharu: 2 articles (01/2015 - 12/2010)
2.	Kanoh, Naoki: 2 articles (01/2015 - 12/2010)
3.	Kataoka, Takao: 2 articles (01/2015 - 12/2010)
4.	Usui, Takeo: 2 articles (01/2015 - 12/2010)
5.	Watanabe, Tsubasa: 2 articles (01/2015 - 12/2010)
6.	Fukuhara, Sayuri: 1 article (01/2015)
7.	Hirano, Seiya: 1 article (01/2015)
8.	Quach, Hue Tu: 1 article (01/2015)
9.	Amagata, Taro: 1 article (01/2012)
10.	Crews, Phillip: 1 article (01/2012)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2023 - "Corrigendum: Psymberin, a marine-derived natural product, induces cancer cell growth arrest and protein translation inhibition." 01/01/2022 - "Psymberin, a marine-derived natural product, induces cancer cell growth arrest and protein translation inhibition." 01/01/2012 - "Solid tumor selective compounds included fascaplysin and 10-bromofascaplysin (Fascaplysinopsis), neoamphimedine, 5-methoxyneoamphimedine and alpkinidine (Xestospongia), makaluvamine C and makaluvamine H (Zyzzya), psymberin (Psammocinia and Ircinia), and ethylplakortide Z and ethyldidehydroplakortide Z (Plakortis). " 12/15/2010 - "Irciniastatin A (ISA)/psymberin, a pederin-type natural product isolated from marine sponge, exhibits extremely potent and selective cytotoxicity against certain human cancer cell lines, but its molecular target and cytotoxic mechanisms are still unknown. "
2.	Carcinoma (Carcinomatosis) 01/01/2015 - "Irciniastatin A induces potent and sustained activation of extracellular signal-regulated kinase and thereby promotes ectodomain shedding of tumor necrosis factor receptor 1 in human lung carcinoma A549 cells." 01/01/2015 - "In human lung carcinoma A549 cells, irciniastatin A induced a marked and sustained activation of extracellular signal-regulated kinase (ERK) and induced little activation of p38 mitogen-activated protein (MAP) kinase and c-Jun N-terminal kinase (JNK). "
3.	Blister (Bulla) 01/18/2007 - "In this letter we describe an efficient synthesis of "psympederin", a hybrid between the novel antitumor natural product psymberin and the blister beetle toxin pederin. "

Related Drugs and Biologics

1.	psymberin
2.	pederin
3.	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)
4.	JNK Mitogen-Activated Protein Kinases
5.	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)
6.	Proteins (Proteins, Gene)
7.	Phosphotransferases (Kinase)
8.	Mitogens
9.	psympederin
10.	neoamphimedine