|1.||Pan, Feng: 4 articles (03/2015 - 07/2013)|
|2.||Kim, Jeong Ah: 4 articles (08/2014 - 12/2004)|
|3.||Yu, Shang Bin: 3 articles (03/2015 - 07/2013)|
|4.||Chen, Yong: 3 articles (03/2015 - 07/2013)|
|5.||Xiong, Xin Xin: 3 articles (03/2015 - 07/2013)|
|6.||Chen, Xiao Qian: 3 articles (03/2015 - 07/2013)|
|7.||Liu, Ju Mei: 3 articles (03/2015 - 07/2013)|
|8.||Uzzo, Robert G: 3 articles (01/2015 - 01/2013)|
|9.||Kolenko, Vladimir M: 3 articles (01/2015 - 01/2013)|
|10.||Kutikov, Alexander: 3 articles (01/2015 - 01/2013)|
|1.||Parkinson Disease (Parkinson's Disease)
08/01/2013 - "Barrier protective effects of piperlonguminine in LPS-induced inflammation in vitro and in vivo."
03/28/2008 - "Taken together, the results indicate that the amide fractions piperovatine and piperlonguminine showed the greatest inhibitory activity of topical inflammation induced by croton oil."
|3.||Breast Neoplasms (Breast Cancer)
04/01/2015 - "In the present study, we observed that human breast cancer MCF-7 cells are sensitive to piperlongumine-induced apoptosis relative to human MCF-10A breast epithelial cells. "
12/01/2014 - "Piperlongumine induces cell death through ROS-mediated CHOP activation and potentiates TRAIL-induced cell death in breast cancer cells."
07/01/2014 - "Piperlongumine, an alkaloid causes inhibition of PI3 K/Akt/mTOR signaling axis to induce caspase-dependent apoptosis in human triple-negative breast cancer cells."
03/12/2015 - "Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with potent activity against breast cancer."
07/01/2014 - "The objective of this study was to investigate the effect of piperlongumine (PPLGM), a natural alkaloid on PI3 K/Akt/mTOR signaling, Akt mediated regulation of NF-kB and apoptosis evasion in human breast cancer cells. "
12/01/2004 - "Piperlonguminine from Piper longum with inhibitory effects on alpha-melanocyte-stimulating hormone-induced melanogenesis in melanoma B16 cells."
02/01/2006 - "Surprisingly, piperlonguminine did not inhibit the catalytic activity of cell-free tyrosinase from melanoma B16 cells but rather suppressed tyrosinase mRNA expression. "
02/01/2006 - "Inhibitory effect of piperlonguminine on melanin production in melanoma B16 cell line by downregulation of tyrosinase expression."
02/01/2006 - "In the present study, piperlonguminine from Piper longum was discovered to inhibit melanin production in melanoma B16 cells stimulated with alpha-melanocyte stimulating hormone (alpha-MSH), 3-isobutyl-1-methylxanthine or protoporphyrin IX, where the compound exhibited stronger depigmenting efficacy than kojic acid. "
|5.||NF-kappa B (NF-kB)
|6.||1-Methyl-3-isobutylxanthine (1 Methyl 3 isobutylxanthine)
|10.||Reactive Oxygen Species (Oxygen Radicals)
|2.||Heterologous Transplantation (Xenotransplantation)