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HCT1027

a cyclooxygenase inhibitor; structure in first source

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Biphenyl Compounds: 7
        Flurbiprofen: 824
        HCT1027: 1
- Carboxylic Acids: 973
  - Acyclic Acids
    - Propionates: 988
      - Flurbiprofen: 824
        HCT1027: 1

Experts

1.	Del Soldato, P: 1 article (09/2004)
2.	Idris, A I: 1 article (09/2004)
3.	Ralston, S H: 1 article (09/2004)
4.	van't Hof, R J: 1 article (09/2004)

Related Diseases

1.

Bone Resorption

09/01/2004 - "We found that HCT1026 and HCT1027 inhibited bone resorption in interleukin (IL)-1-stimulated murine osteoblast-bone marrow cocultures, with half-maximal effects (IC50) at 20 +/- 5 microM for HCT1026 and 25 +/- 6 microM for HCT1027 compared with 399 +/- 25 microM for flurbiprofen (P < 0.0001). "
09/01/2004 - "The flurbiprofen derivatives HCT1026 and HCT1027 inhibit bone resorption by a mechanism independent of COX inhibition and nitric oxide production."

Related Drugs and Biologics

1.	Nitric Oxide (Nitrogen Monoxide)
2.	Interleukins
3.	Flurbiprofen (Froben)
4.	nitroflurbiprofen