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2- (4- fluorophenyl)- 4- (1- phenethyl- 1,2,3,6- tetrahydropyridin- 4- yl)- 3- (pyridin- 4- yl)- 1H- pyrrole

MAP kinase inhibitor; structure in first source

Also Known As:

R-130823

Networked: 3 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrroles: 369
      - 2-(4-fluorophenyl)-4-(1-phenethyl-1,2,3,6-tetrahydropyridin-4-yl)-3-(pyridin-4-yl)-1H-pyrrole: 3
  - Pyridines: 88
    - 2-(4-fluorophenyl)-4-(1-phenethyl-1,2,3,6-tetrahydropyridin-4-yl)-3-(pyridin-4-yl)-1H-pyrrole: 3

Experts

1.	Kimura, Tomio: 3 articles (02/2006 - 01/2005)
2.	Ushiyama, Shigeru: 3 articles (02/2006 - 01/2005)
3.	Wada, Yoshihiro: 3 articles (02/2006 - 01/2005)
4.	Shimada, Kohei: 2 articles (02/2006 - 10/2005)
5.	Sugimoto, Kotaro: 1 article (02/2006)
6.	Aoki, Kazumasa: 1 article (01/2005)
7.	Nakajima-Yamada, Tomoko: 1 article (01/2005)
8.	Shimozato, Takaichi: 1 article (01/2005)
9.	Tsuchida, Jun: 1 article (01/2005)
10.	Yamada, Kazuyo: 1 article (01/2005)

Related Diseases

1.	Hyperalgesia 01/04/2005 - "R-130823, a novel inhibitor of p38 MAPK, ameliorates hyperalgesia and swelling in arthritis models." 01/04/2005 - "In the same model, R-130823 ameliorated adjuvant-induced hyperalgesia with rapid onset and long duration comparable to a cyclooxygenase-2 inhibitor, celecoxib. "
2.	Arthritis (Polyarthritis) 01/04/2005 - "In murine collagen-induced arthritis, R-130823 blocked the progress of arthritis when administered just after the onset of the arthritis. " 01/04/2005 - "R-130823 reduced the established hind paw swelling in rat adjuvant-induced arthritis, while methotrexate showed no suppression. " 01/04/2005 - "R-130823, a novel inhibitor of p38 MAPK, ameliorates hyperalgesia and swelling in arthritis models."
3.	Osteoarthritis 02/01/2006 - "In order to study the involvement of mitogen-activated protein kinase p38 in osteoarthritis, we investigated the effect of novel p38 inhibitor R-130823 {2-(4-fluorophenyl)-4-(1-phenethyl-1,2,3,6-tetrahydropyridin-4-yl)-3-(pyridin-4-yl)-1H-pyrrole} on human chondrocytes and bovine cartilage. "
4.	Synovial Sarcoma (Synovioma) 10/15/2005 - "Novel p38 MAP kinase inhibitor R-130823 suppresses IL-6, IL-8 and MMP-13 production in spheroid culture of human synovial sarcoma cell line SW 982."
5.	Rheumatoid Arthritis 01/04/2005 - "In conclusion, R-130823 is expected to be an efficacious treatment for rheumatoid arthritis by blocking the p38 pathway."

Related Drugs and Biologics

1.	p38 Mitogen-Activated Protein Kinases
2.	Pyrroles
3.	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)
4.	Interleukin-8 (Interleukin 8)
5.	Interleukin-6 (Interleukin 6)
6.	Methotrexate (Mexate)
7.	Celecoxib (Celebrex)