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4-(5-naphthyl-3- (trifluoromethyl)- 1H- pyrazol- 1- yl)benzenesulfonamide

inhibits cell viability and induces apoptosis in human colon cancer SW-1116 cells; structure in first source

Also Known As:

PC-407

Networked: 2 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Fan, Lei: 1 article (12/2009)
2.	Huang, Haitao: 1 article (12/2009)
3.	Li, Qian: 1 article (12/2009)
4.	Li, Yuhua: 1 article (12/2009)
5.	Liu, Li: 1 article (12/2009)
6.	Mei, Qibing: 1 article (12/2009)
7.	Niu, Yinbo: 1 article (12/2009)
8.	Sun, Yang: 1 article (12/2009)
9.	Wu, Huanjie: 1 article (12/2009)
10.	Zhang, Bangle: 1 article (12/2009)

Related Diseases

1.	Colorectal Neoplasms (Colorectal Cancer) 12/01/2009 - "PC-407, a celecoxib derivative, inhibited the growth of colorectal tumor in vitro and in vivo." 12/01/2009 - "This study aimed to observe the growth-inhibitory effect of PC-407 (4-[5-naphthyl-3-(trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamide), a celecoxib derivative synthesized in our lab, in human colorectal cancer cells and a colitis-associated colorectal cancer (CACC) model, and investigate the relative molecular mechanisms. "
2.	Colonic Neoplasms (Colon Cancer) 11/01/2004 - "PC-407 inhibited proliferation and induced apoptosis in the human colon cancer SW-1116 cell line." 11/01/2004 - "PC-407 inhibited proliferation and induced apoptosis in human colon cancer SW-1116 cells." 11/01/2004 - "To study whether PC-407 [4-[5-naphthyl-3- (trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamide] inhibits cell viability and induces apoptosis in human colon cancer SW-1116 cells. "
3.	Colitis-Associated Neoplasms 12/01/2009 - "This study aimed to observe the growth-inhibitory effect of PC-407 (4-[5-naphthyl-3-(trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamide), a celecoxib derivative synthesized in our lab, in human colorectal cancer cells and a colitis-associated colorectal cancer (CACC) model, and investigate the relative molecular mechanisms. "
4.	Carcinogenesis 12/01/2009 - "A mouse model of colitis-associated carcinogenesis was employed to determine the effect of PC-407 in vivo. "
5.	Neoplasms (Cancer) 12/01/2009 - "Our data indicate that PC-407 can inhibit the growth of tumor both in vitro and in vivo and suggest that the effect probably involves inhibition of the COX-2 pathway and other COX-2-independent pathways."

Related Drugs and Biologics

1.	Benzenesulfonamides
2.	Chloride Channels (Chloride Channel)
3.	Celecoxib (Celebrex)