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N-retinylidene-phosphatidylethanolamine

putative substrate of ABCA4

Also Known As:

N-retinylidene-PE

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Molday, Robert S: 3 articles (11/2020 - 06/2012)
2.	Curtis, Susan B: 1 article (11/2020)
3.	Garces, Fabian A: 1 article (11/2020)
4.	Molday, Laurie L: 1 article (11/2020)
5.	Orban, Tivadar: 1 article (05/2013)
6.	Palczewski, Krzysztof: 1 article (05/2013)
7.	Taylor, Derek: 1 article (05/2013)
8.	Tsybovsky, Yaroslav: 1 article (05/2013)
9.	Lenevich, Stepan: 1 article (06/2012)
10.	Quazi, Faraz: 1 article (06/2012)

Related Diseases

1.	Stargardt Disease 06/26/2012 - "Mutations known to cause Stargardt disease decrease N-retinylidene-phosphatidylethanolamine and phosphatidylethanolamine transport activity of ABCA4. " 11/01/2020 - "Stargardt macular degeneration (Stargardt disease 1 [STGD1]) is caused by mutations in the gene encoding ABCA4, an ATP-binding cassette protein that transports N-retinylidene-phosphatidylethanolamine (N-Ret-PE) across photoreceptor membranes. " 06/26/2012 - "Here we show that ABCA4, an ABC transporter found in retinal photoreceptor cells and associated with Stargardt macular degeneration, is a novel importer that actively flips N-retinylidene-phosphatidylethanolamine from the lumen to the cytoplasmic leaflet of disc membranes, thereby facilitating the removal of potentially toxic retinoid compounds from photoreceptors. "
2.	Macular Degeneration (Age-Related Maculopathy) 05/07/2013 - "This protein transports N-retinylidene-phosphatidylethanolamine to the outer side of disc membranes to prevent formation of toxic compounds causing macular degeneration. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	ATP-Binding Cassette Transporters (ABC Transporters)
3.	Retinoids
4.	Adenosine Triphosphate (ATP)
5.	phosphatidylethanolamine