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TX-1898

angiogenesis inhibitor; structure in first source

Also Known As:

R-p-tert-butylphenyl-bromoacetylcarbamoyl-2-nitroimidazole

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Nitro Compounds: 66
  - Nitroimidazoles: 565
    - TX-1898: 1
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - Nitroimidazoles: 565
        TX-1898: 1

Experts

1.	Hori, Hitoshi: 1 article (12/2006)
2.	Kirk, Kenneth Lee: 1 article (12/2006)
3.	Nagasawa, Hideko: 1 article (12/2006)
4.	Uto, Yoshihiro: 1 article (12/2006)

Related Diseases

1.

Hypoxia (Hypoxemia)

12/01/2006 - "Based on these considerations, we developed the antiangiogenic hypoxic cell radiosensitizers, TX-1877, TX-1898 and the hypoxic cytotoxin TX-402 that inhibits the HIF-1alpha pathway We will also discuss our research involved with the development of other drugs to exploit tumor hypoxia, including a hypoxia-targeting boron carrier for boron neutron capture therapy (BNCT) and a p53 inhibiting radiosensitizer."

Related Drugs and Biologics

1.	Cytotoxins (Cytolysins)
2.	Boron
3.	3-amino-2-quinoxalinecarbonitrile
4.	2-nitroimidazole acetamide

Related Therapies and Procedures

1.	Boron Neutron Capture Therapy