abrine

01/01/2022 - "Abrine Elicits Liver Carcinoma Immunity and Enhances Antitumor Efficacy of Immune Checkpoint Blockade by Modulating PD-L1 Signaling."

01/01/2023 - "The PD-1/PD-L1 axis is an important immune checkpoint in regulating immune response, overexpression of PD-1 or PD-L1 promotes immune suppression, while in this study Abrine could inhibit the expression of PD-L1 in cancer cells or tumor tissue. "
01/01/2023 - "The combination treatment of Abrine and anti-PD-1 antibody has a synergistic effect on suppressing the tumor growth through up-regulating CD4+ or CD8+ T cells, down-regulating the Foxp3+ Treg cells, and inhibiting the expression of IDO1, CD47, and PD-L1. "
01/01/2023 - "CD47 is IFN-γ-stimulated genes (ISGs) and prevents the phagocytosis of macrophages, leading to the cancer immune escape, and this effect could be inhibited by Abrine both in vivo and in vitro. "
01/01/2022 - "Ectopic expression of KAT5 and PD-L1 reversed the function of abrine on tumor growth and T cell function. "
01/01/2022 - "Abrine treatment suppressed liver tumor growth both in vitro and in vivo and simultaneously decreased the level of PD-L1 and KAT5. "

02/01/2021 - "The Centers for Disease Control and Prevention's Laboratory Response Network detected abrine in the urine confirming abrin exposure in this fatal poisoning."
12/01/2014 - "This is the first case of human abrin toxin poisoning confirmed by the quantitation of L-abrine as a biomarker. "
12/01/2014 - "We report the presentation of a single case of unintentional abrin poisoning confirmed by the quantitation of L-abrine biomarker. "
12/01/2014 - "A case of abrin toxin poisoning, confirmed via quantitation of L-abrine (N-methyl-L-tryptophan) biomarker."
04/15/2014 - "Using an immobilization strategy that implements non-natural amino acids for site-specific conjugation, we have created a reusable N-methyltryptophan oxidase based magnetic bead system that is capable of detecting L-abrine, a marker for abrin poisoning, at concentrations as low as 4 μM in mock urine. "

02/01/2022 - "Abrine promotes cell proliferation and inhibits apoptosis of interleukin-1β-stimulated chondrocytes via PIM2/VEGF signalling in osteoarthritis."

01/01/2022 - "Abrine modulated growth and apoptosis of liver cancer cells and regulated proliferation and activation of T cells through the KAT5/PD-L1 axis."
01/01/2022 - "This work is aimed at studying the effects of abrine in immunity of liver cancer. "