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N- ((3- (aminomethyl)phenyl)methyl)ethanimidamide

Also Known As:
1400 W
Networked: 25 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Stehr, A: 2 articles (06/2003 - 09/2001)
2. Radermacher, P: 2 articles (06/2003 - 09/2001)
3. Ploner, F: 2 articles (06/2003 - 09/2001)
4. Tugtekin, I: 2 articles (06/2003 - 09/2001)
5. Theisen, M: 2 articles (06/2003 - 09/2001)
6. Georgieff, M: 2 articles (06/2003 - 09/2001)
7. Matejovic, M: 2 articles (06/2003 - 09/2001)
8. Wu, Houdini Ho Tin: 1 article (01/2013)
9. Sims, Robert Edward: 1 article (01/2013)
10. Dale, Nicholas: 1 article (01/2013)

Related Diseases

1. Endotoxemia
09/01/2001 - "Therefore, this study investigated the effect of selective inducible NOS (iNOS) inhibition using 1400 W on intestinal and liver perfusion, O2 kinetics, and energy metabolism during hyperdynamic porcine endotoxemia. "
09/01/2001 - "After 12 h of endotoxemia, continuous intravenous infusion of 1400 W was started until the end of the experiment and was titrated to maintain mean blood pressure (MAP) at baseline levels. "
11/01/2006 - "During late endotoxemia (8 h after LPS), both iNOS inhibition (N = 9) and TNF-alpha neutralization (N = 9) reversed the increase of GR (%GR 33.7 +/- 2.0 vs 19.1 +/- 2.6% (1400 W) and 20.1 +/- 2.0% (anti-TNF-alpha)), but only TNF-alpha neutralization reversed the delay of GIT (geometric center 3.9 +/- 0.4 vs 5.9 +/- 0.2). "
11/01/2006 - "During early endotoxemia (1.5 h after LPS), inhibition of inducible NO synthase (iNOS) by a selective inhibitor, 1400 W (150 microg/mouse, N = 11), but not antibody neutralization of TNF-alpha (200 microg/mouse, N = 11), reversed the increase of GR (%GR 78.8 +/- 3.3 vs 47.2 +/- 7.5%) and the delay of GIT (geometric center 3.7 +/- 0.4 vs 5.6 +/- 0.2). "
04/01/2003 - "This study examined the effects of 1400 W (N-3-aminomethyl-benzyl-acetamidine), a new selective inhibitor of inducible NOS (iNOS), relative to those of N(G)-nitro-L-arginine (L-NNA, non-selective inhibitor of NOS) and the vehicle, on mean arterial pressure (MAP), CO, total peripheral resistance (TPR) and tissue blood flow (BF) in thiobutabarbital-anesthetized rats with lipopolysaccharide (LPS, 10 mg/kg, i.v.) induced endotoxemia. "
2. Insulin Resistance
3. AIDS-Related Complex (ARC)
4. Ischemia
5. Shock

Related Drugs and Biologics

1. Carbon Monoxide
2. Peroxynitrous Acid (Peroxynitrite)
3. Arginine (L-Arginine)
4. thiobutabarbital (Inactin)
5. Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)
6. NG-Nitroarginine Methyl Ester (L-NAME)
7. Nitric Oxide Synthase (NO Synthase)
8. acetamidine
9. 3-nitrotyrosine
10. Leptin

Related Therapies and Procedures

1. Resuscitation
2. Positive-Pressure Respiration (PEEP)
3. Intravenous Infusions