|1.||Zahradka, Peter: 3 articles (02/2015 - 06/2004)|
|2.||Taylor, Carla G: 3 articles (02/2015 - 06/2004)|
|3.||Kennedy, Arion: 3 articles (03/2013 - 06/2010)|
|4.||Martinez, Kristina: 3 articles (03/2013 - 06/2010)|
|5.||Ogborn, Malcolm R: 2 articles (02/2015 - 02/2009)|
|6.||Aukema, Harold M: 2 articles (02/2015 - 02/2009)|
|7.||McIntosh, Michael: 2 articles (03/2013 - 06/2010)|
|8.||Ha, Yeong L: 2 articles (07/2008 - 08/2002)|
|9.||Cook, Mark E: 2 articles (08/2007 - 11/2006)|
|10.||Stanton, Catherine: 2 articles (08/2007 - 11/2002)|
|1.||Colonic Neoplasms (Colon Cancer)
04/01/2013 - "In this study, we carried out to precise the effects of CLA isomers, c9,t11 and t10,c12 CLA, on mechanisms of cell death induction in colon cancer cells. "
04/01/2013 - "These results highlight that t10,c12 CLA exerts its cytotoxic effect through ROS generation and a subsequent ER stress-dependent apoptosis in colon cancer cells."
04/01/2013 - "We first showed that only t10,c12 CLA treatment (25 and 50μM) for 72h triggered apoptosis in colon cancer cells without affecting viability of normal-derived colon epithelial cells. "
08/01/2002 - "Trans-10,cis-12-conjugated linoleic acid inhibits Caco-2 colon cancer cell growth."
10/01/2007 - "We have demonstrated that diets containing 0.1% c9,t11 and t10,c12 CLA were equally effective in inhibiting colon cancer cell metastasis in vivo. "
06/01/2004 - "To date, rodent studies suggest that trans-10,cis-12 (t10,c12) CLA is associated with greater insulin resistance, despite lower body fat, and that a CLA mixture (and perhaps c9,t11) could be beneficial for the management of insulin resistance. "
06/04/2010 - "We showed previously in cultures of primary human adipocytes and preadipocytes that lipopolysaccharide and trans-10,cis-12-conjugated linoleic acid (10,12-CLA) activate the inflammatory signaling that promotes insulin resistance. "
10/01/2011 - "However, these anti-obesity actions of t10,c12 CLA are routinely accompanied by increased markers of inflammation and insulin resistance. "
10/01/2011 - "Thus, we examined the extent to which blocking c-Jun NH2-terminal kinase (JNK) signaling using the JNK inhibitor SP600125 attenuated markers of inflammation and insulin resistance in primary human adipocytes treated with t10,c12 CLA. "
10/01/2009 - "However, insulin resistance and liver hypertrophy were observed in t10,c12 CLA and CLA mix groups based on the results of homeostasis model assessment, revised quantitative insulin-sensitivity check index (R-QUICKI), intravenous glucose tolerance test, and liver histology. "
|3.||Neoplasm Metastasis (Metastasis)
|4.||Body Weight (Weight, Body)
02/01/2009 - "In study 2, diet also did not affect body weights, but fa/fa rats given a diet containing t10,c12 CLA had 7% lower kidney weights, 20% smaller glomeruli, and 39% lower COX-2 protein levels than CTL rats. "
11/01/2006 - "Dietary c9,t11 or t10,c12 CLA led to body weight loss intermediate to controls and cCLA. "
10/01/2011 - "Supplementation with a mixture of trans-10, cis-12 (t10,c12) and cis-9, trans-11 (c9,t11) isomers of conjugated linoleic acid (CLA), or t10,c12 CLA alone, reduces body weight and fat deposition in animals and some humans. "
01/01/2009 - "This study tested the hypothesis that the effect of trans-10, cis-12 conjugated linoleic acid (t10, c12 CLA) on energy intake (EI) and body weight (BW)/composition is confounded by dietary fat concentration and involves hypothalamic appetite-controlling mechanisms. "
10/01/2012 - "c9, t11 CLA and the commercial CLA mix showed beneficial effects on insulin sensitivity compared with LA, while t10, c12 CLA adversely affects body weight and insulin sensitivity in different PPAR genotypes. "
11/01/2002 - "The aim of this study was to evaluate the effects of three commercial CLA preparations (pure c9, t11-CLA, pure t10, c12-CLA and a CLA mixture, containing 29.5% c9, t11 and 29% t10, c12-CLA) on caspase-dependent apoptosis in colon SW480 tumor cells. "
04/01/2013 - "Furthermore, we evidenced that inhibition of CHOP expression and JNK signaling decreased t10,c12 CLA-mediated cancer cell death. "
01/01/2009 - "Human primary muscle cells were grown in coculture with MIA PaCa-2 pancreatic tumor cells and exposed to varying concentrations of c9,t11 and t10,c12 CLA. "
05/18/2007 - "Here, we report that t10,c12 CLA, a component of synthetic CLA supplements, induced apoptosis and G1 arrest of p53 mutant TM4t murine mammary tumor cells. "
08/01/2007 - "coli contained a mixture of linoleic acid and t10, c12 CLA at a ratio of approximately 1.35 : 1. Following 5 days of incubation of SW480 cells with 5-20 microg ml(-1) (17.8-71.3 microM) of the t10, c12 CLA, there was a significant (P<0.001) reduction in growth of the SW480 cancer cells compared with the linoleic acid control. "
|1.||Linoleic Acid (Linoleate)
|3.||Dietary Fats (Ghee)
|5.||Insulin Receptor Substrate Proteins
|7.||Peroxisome Proliferator-Activated Receptors (PPAR)
|8.||Oleic Acid (Oleate)
|9.||Messenger RNA (mRNA)
|10.||Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)