Focal Adhesion Kinase 1

A non-receptor protein tyrosine kinase with PROTEIN PHOSPHATASE 1 regulatory activity that is localized to FOCAL ADHESIONS and is a central component of integrin-mediated SIGNAL TRANSDUCTION PATHWAYS. Focal adhesion kinase 1 interacts with PAXILLIN and undergoes PHOSPHORYLATION in response to adhesion of cell surface integrins to the EXTRACELLULAR MATRIX. Phosphorylated p125FAK protein binds to a variety of SH2 DOMAIN and SH3 DOMAIN containing proteins and helps regulate CELL ADHESION and CELL MIGRATION.

Also Known As:

Endogenous Substrate pp120; Focal Adhesion-Associated Protein-Tyrosine Kinase pp125FAK; Protein Tyrosine Kinase 2; p125FAK Protein; Focal Adhesion Associated Protein Tyrosine Kinase pp125FAK

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Phosphotransferases: 42769
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 9677
        Protein-Tyrosine Kinases: 7697
        Focal Adhesion Protein-Tyrosine Kinases: 1701
        Focal Adhesion Kinase 1: 56
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Phosphoproteins: 1772
    - Focal Adhesion Kinase 1: 56
  - Intracellular Signaling Peptides and Proteins: 32
    - Protein-Tyrosine Kinases: 7697
      - Focal Adhesion Protein-Tyrosine Kinases: 1701
        Focal Adhesion Kinase 1: 56

Drosophila Fak protein

Bio-Agent Context: Research Results