|1.||Kim, Nam-Hyung: 1 article (06/2015)|
|2.||Lin, Zi-Li: 1 article (06/2015)|
|3.||Alekseev, Oleg: 1 article (02/2014)|
|4.||Donovan, Kelly: 1 article (02/2014)|
|5.||Azizkhan-Clifford, Jane: 1 article (02/2014)|
|6.||Chen, Junjie: 1 article (12/2012)|
|7.||Shrivastav, Meena: 1 article (12/2012)|
|8.||Nadkarni, Aditi: 1 article (12/2012)|
|9.||Grogan, Patrick T: 1 article (12/2012)|
|10.||Mladek, Ann C: 1 article (12/2012)|
01/01/2010 - "Moreover, KU-55933 inhibits cancer cell proliferation by inducing G(1) cell cycle arrest. "
01/01/2010 - "The ATM inhibitor KU-55933 suppresses cell proliferation and induces apoptosis by blocking Akt in cancer cells with overactivated Akt."
01/01/2010 - "In addition, KU-55933 treatment during serum starvation triggers apoptosis in these cancer cells. "
05/01/2007 - "Moreover, Fanconi anemia complementation group G- (FANCG-) and FANCC-deficient pancreatic tumor lines were more sensitive to the ATM inhibitor KU-55933 than isogenic corrected lines. "
01/01/2010 - "Combination of KU-55933 and rapamycin not only induces apoptosis, which is not seen in cancer cells treated only with rapamycin, but also shows better efficacy in inhibiting cancer cell proliferation than each drug alone. "
|2.||Ataxia Telangiectasia (Louis Bar Syndrome)
01/01/2012 - "In view of prior preliminary evidence suggesting defective mitochondrial function in cells of patients with Ataxia Telangiectasia (AT), we examined energy metabolism of cells treated with KU-55933. "
12/01/2009 - "The ataxia-telangiectasia mutated (ATM) inhibitor KU-55933 increased radiation sensitivity and delayed repair of radiation-induced DNA breaks, but did not influence TMZ effects. "
12/15/2004 - "By contrast, KU-55933 did not potentiate the cytotoxic effects of ionizing radiation on ataxia-telangiectasia cells, nor did it affect their cell cycle profile after DNA damage. "
01/01/2012 - "KU-55933 is a specific inhibitor of the kinase activity of the protein encoded by Ataxia telangiectasia mutated (ATM), an important tumor suppressor gene with key roles in DNA repair. "
09/01/2007 - "Ataxia-telangiectasia (A-T) patient fibroblasts, wild-type fibroblasts treated with the ATM inhibitor KU-55933, and cells in which RR is inhibited pharmacologically or by RNA interference (RNAi) each lead to mitochondrial DNA (mtDNA) depletion under normal growth conditions. "
12/01/2012 - "In parental U251 and U87 glioma lines, the addition of KU-55933 to TMZ significantly increased cell killing compared to TMZ alone [U251 survival: 0.004 ± 0.0015 vs. 0.08 ± 0.01 (p < 0.001), respectively, and U87 survival: 0.02 ± 0.005 vs. 0.04 ± 0.002 (p < 0.001), respectively] and also elevated the fraction of cells arrested in G2/M [U251 G2/M fraction: 61.8 ± 1.1 % vs. 35 ± 0.8 % (p < 0.001), respectively, and U87 G2/M fraction 25 ± 0.2 % vs.18.6 ± 0.4 % (p < 0.001), respectively]. "
10/01/2009 - "KU-60019 is 10-fold more effective than KU-55933 at blocking radiation-induced phosphorylation of key ATM targets in human glioma cells. "
|4.||Nijmegen Breakage Syndrome
|1.||Insulin-Like Growth Factor I (IGF-1)
|4.||Bone Morphogenetic Protein 15
|5.||Growth Differentiation Factor 9
|6.||AMP-Activated Protein Kinases
|7.||DNA-Activated Protein Kinase
|9.||NF-kappa B (NF-kB)
|10.||Messenger RNA (mRNA)
|2.||Drug Therapy (Chemotherapy)