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4- (2- methylthiophenyl)- N- (1,2,3,4- tetrahydronaphthalen- 1- yl)- 1- piperazinehexanamide

a 5-HT(7) receptor agonist; structure in first source

Also Known As:

LP-44; MTNPHNH2

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperazines: 26
    - 4-(2-methylthiophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazinehexanamide: 2
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Naphthalenes: 18
        Tetrahydronaphthalenes: 1
        4-(2-methylthiophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazinehexanamide: 2
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthalenes: 18
    - Tetrahydronaphthalenes: 1
      - 4-(2-methylthiophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazinehexanamide: 2

Experts

1.	Altamirano-Reyna, Frida: 1 article (01/2018)
2.	Arreola-Peralta, Luis D: 1 article (01/2018)
3.	Galindo-González, Deni M: 1 article (01/2018)
4.	Lacivita, Enza: 1 article (01/2018)
5.	Leopoldo, Marcello: 1 article (01/2018)
6.	Solis-Anguiano, Jessica G: 1 article (01/2018)
7.	Terrón, José A: 1 article (01/2018)
8.	Albayrak, Abdulmecit: 1 article (02/2017)
9.	Bayir, Yasin: 1 article (02/2017)
10.	Cadirci, Elif: 1 article (02/2017)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2018 - "Interestingly, LP-44 by itself also produced inflammation in a concentration- and time-dependent manner, and magnified CAP-induced responses. " 01/01/2018 - "Systemic pre-treatment with SB-269970 significantly blunted LP-44 (15 nmol)-induced inflammation as well as magnified inflammatory responses produced by the combination of LP-44 (7.5 and 15 nmol) + CAP (0.1%) thus confirming the involvement of 5-HT7 receptors. " 02/01/2017 - "5-HT7 receptor agonist LP-44 showed significant hepatoprotective effects against liver fibrosis, and LP-44 might become a useful therapeutic target for chronic liver inflammation and fibrosis."
2.	Neurogenic Inflammation 01/01/2018 - "We analysed the modulation of capsaicin (CAP)-induced neurogenic inflammation in the rat hind paw by the selective 5-HT7 receptor agonist, LP-44, and the involvement of calcitonin gen-related peptide (CGRP) in this effect. "
3.	Liver Cirrhosis (Hepatic Cirrhosis) 02/01/2017 - "5-HT7 receptor agonist LP-44 showed significant hepatoprotective effects against liver fibrosis, and LP-44 might become a useful therapeutic target for chronic liver inflammation and fibrosis."
4.	Fibrosis (Cirrhosis) 02/01/2017 - "5-HT7 receptor agonist LP-44 showed significant hepatoprotective effects against liver fibrosis, and LP-44 might become a useful therapeutic target for chronic liver inflammation and fibrosis."

Related Drugs and Biologics

1.	serotonin 7 receptor
2.	Peptides (Polypeptides)
3.	Capsaicin (Zostrix)
4.	Calcitonin (Calcitonin, Eel)
5.	SB 269970