apelin-12 peptide

11/01/2015 - "Signaling pathways of a structural analogue of apelin-12 involved in myocardial protection against ischemia/reperfusion injury."
01/01/2018 - "When an ischemia-reperfusion injury occurred, Apelin-12 can inhibit the JNK and P38MAPK signaling pathway of the apoptosis-related MAPKs family, thus offering protection to neurons."
11/01/2011 - "In vivo reduction of reperfusion injury to the heart with apelin-12 peptide in rats."
01/01/2018 - "Apelin-12 significantly improved the neurobehavioral score of the mice with ischemia-reperfusion injury, alleviated brain edema and the damage to neurons. "
01/01/2018 - "Apelin-12 exerts neuroprotective effect against ischemia-reperfusion injury by inhibiting JNK and P38MAPK signaling pathway in mouse."

11/06/2023 - "• Higher serum apelin-12 was observed in obese-DS and obese-DS with MetS than obese-control and obese-control with MetS respectively. The increase in apelin-12 level with increasing obesity grades was more pronounced in obese-DS. "
11/06/2023 - "The increase in apelin-12 with higher obesity grades was pronounced in obese-DS. "
11/06/2023 - "ROC curves were analyzed to evaluate the efficiency of apelin-12 in predicting MetS in obesity groups. "
01/01/2014 - "Associations between serum apelin-12 levels and obesity-related markers in Chinese children."
01/01/2019 - "In obese individuals, aerobic and resistance exercise were effective in improving obesity and reducing blood apelin-12 concentration, which is closely correlated with indicators of metabolic syndrome. "

11/01/2020 - "In logistic regressions, we identified that apelin-12 was a risk factor for metabolic syndrome, and adropin was a protecting factor of having MetS after adjusting for age, sex, and puberty. "
11/01/2020 - "Adropin and apelin-12 efficiently predict metabolic syndrome in obese children."
01/01/2019 - "In obese individuals, aerobic and resistance exercise were effective in improving obesity and reducing blood apelin-12 concentration, which is closely correlated with indicators of metabolic syndrome. "
11/06/2023 - "This study aimed to explore the possible association between serum apelin-12 and obesity-related markers and to evaluate the efficiency of apelin-12 in the prediction of metabolic syndrome (MetS) in obese-DS compared to BMI Z-score matched obese-control. "
11/01/2020 - "Furthermore, ROC analysis revealed that adropin and apelin-12 are more sensitive predictors of metabolic syndrome than leptin and adiponectin. "

11/01/2015 - "Exogenously administered chemically modified apelin-12 (MA) has been shown to exhibit protective effects in myocardial ischemia/reperfusion (I/R) injury. "
06/01/2014 - "Apelin-12 and its structural analog enhance antioxidant defense in experimental myocardial ischemia and reperfusion."
01/01/2020 - "Chemically modified peptide apelin-12 ([MeArg1, NLe10]-apelin12, peptide M) is able to reduce reactive oxygen species (ROS) formation, cell death, and metabolic and ionic homeostasis disorders in experimental myocardial ischemia-reperfusion injury. "
01/01/2013 - "Effects of apelin-12 H-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH (A12) and its modified analogue H-(NMe)Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Nle-Pro-Phe-OH (I) on activity of antioxidant enzymes, formation of malonic dialdehyde (MDA) and generation of reactive oxygen species (ROS) were studied in ex vivo and in vivo models of myocardial ischemia and reperfusion (I/R) injury in Wistar rats. "
06/01/2014 - "This study investigated the effects of peptide apelin-12 (H-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH, A12) and its novel structural analog (H-(N(α)Me)Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Nle-Pro-Phe-OH, AI) on myocardial antioxidant enzyme activities, lipid peroxidation, and reactive oxygen species formation in ex vivo and in vivo models of myocardial ischemia/reperfusion (I/R) injury. "

01/01/2010 - "[Effects of exogenous apelin-12 on functional and metabolic recovery of isolated rat heart after ischemia]."
05/01/2018 - "Protective effects of a modified apelin-12 and dinitrosyl iron complexes in experimental cardioplegic ischemia and reperfusion."
07/01/2013 - "To examine cardioprotective effects of Ρ-terminal fragment of adipokine apelin-12 (A12), its novel structural analogue [MeArg(1), NLe(10)]-A12 (I), and [d-Ala(12)]-A12 (II), a putative antagonist of APJ receptor, employing in vivo model of ischemia/reperfusion (I/R) injury. "
01/01/2013 - "[Antioxidant properties of apelin-12 and its structural analogue in experimental ischemia and reperfusion]."
11/01/2012 - "Effects of apelin-12 (a peptide comprised of 12 aminoacids, A-12) on recovery of energy metabolism and cardiac function were studied in isolated working rat hearts perfused with Krebs buffer (KB) containing 11 mM glucose that were subjected to global ischemia and reperfusion. "