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1- (beta- naphthylmethyl)- 6,7- dihydroxy- 1,2,3,4- tetra- hydroisoquinoline (YS 51)

structure in first source

Also Known As:

YS 51; 1-(beta-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline; YS-51

Networked: 4 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Isoquinolines: 34
      - Tetrahydroisoquinolines: 44
        1-(beta-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetra-hydroisoquinoline: 4

Experts

1.	Chang, Ki Churl: 3 articles (06/2004 - 05/2002)
2.	Yun-Choi, Hye Sook: 3 articles (06/2004 - 05/2002)
3.	Kang, Young Jin: 2 articles (06/2004 - 05/2002)
4.	Kim, Hyo Jung: 1 article (06/2004)
5.	Ko, Young Shin: 1 article (06/2004)
6.	Lee, Young Soo: 1 article (06/2004)
7.	Park, Min Kyu: 1 article (06/2004)
8.	Pyo, Hyang Sam: 1 article (06/2004)
9.	Seo, Han Geuk: 1 article (06/2004)
10.	Lee, Duck Hyung: 1 article (01/2004)

Related Diseases

1.	Septic Shock (Toxic Shock Syndrome) 05/01/2002 - "These data strongly suggest that YS 51, a positional isomer of YS 49, might be beneficial in septic shock and/or endotoxin-induced inflammatory disorders."
2.	Thrombosis (Thrombus) 11/15/2001 - "The antithrombotic effects of YS-49 and YS-51 were also observed in both mouse acute thrombosis model and rat arterio-venous shunt (AV shunt) model. " 11/15/2001 - "The oral administration of YS-49 and YS-51 (50 or 100 mg/kg) increased the recovery rates from the acute thrombotic challenge in mice and lowered the weight of thrombus formed inside the AV shunt tube in rats."
3.	Shock 05/01/2002 - "A synthetic isoquinoline alkaloid, 1-(beta-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (YS 51), reduces inducible nitric oxide synthase expression and improves survival in a rodent model of endotoxic shock."
4.	Multiple Organ Failure (MODS) 01/01/2004 - "The above results suggest that YS-49 and YS-51 have therapeutic potential for DIC and/or accompanying multiple organ failure."
5.	Carcinoma (Carcinomatosis) 06/01/2004 - "The effect of YS 51, a synthetic 1-(beta-naphtylmethyl)6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline alkaloid, on the expression of manganese-superoxide dismutase (Mn-SOD), an antioxidant enzyme, was examined in sheep pulmonary artery endothelial cells (SPAEC) and a human cervical carcinoma cell line (Hela). "

Related Drugs and Biologics

1.	YS 49
2.	Endotoxins
3.	Alkaloids
4.	1- (beta- naphthylmethyl)- 6,7- dihydroxy- 1,2,3,4- tetra- hydroisoquinoline (YS 51)
5.	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)
6.	Superoxide Dismutase
7.	Enzymes
8.	Dacarbazine (DIC)
9.	Antioxidants
10.	isoquinoline

Related Therapies and Procedures

1.	Oral Administration