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soymetide-4

an fMLP agonist peptide derived from the beta-conglycinin alpha'-subunit

Also Known As:

MITL peptide; Met-Ile-Thr-Leu; methionyl-isoleucyl-threonyl-leucine

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Tsuruki, Takahiro: 2 articles (05/2005 - 05/2004)
2.	Yoshikawa, Masaaki: 2 articles (05/2005 - 05/2004)
3.	Takahata, Kyoya: 1 article (05/2005)

Related Diseases

1.	Alopecia (Baldness) 05/01/2004 - "Design of soymetide-4 derivatives to potentiate the anti-alopecia effect." 05/01/2004 - "The anti-alopecia effect of [Trp](3)-soymetide-4 was about 3 times larger than that of soymetide-4 after oral administration." 05/01/2005 - "Anti-alopecia effect of soymetide-4 was also blocked by pyrrolidine dithiocarbamate, an inhibitor of nuclear factor-kappaB (NF-kappaB). " 05/01/2005 - "Anti-alopecia mechanisms of soymetide-4, an immunostimulating peptide derived from soy beta-conglycinin." 05/01/2005 - "These results suggest that PGE2, which is produced after activation of COX by soymetide-4, might suppress apoptosis of hair matrix cells and etoposide-induced alopecia by activating NF-kappaB."
2.	Neoplasms (Cancer) 05/01/2005 - "Previously, we found that orally administered soymetide-4 (MITL), an immunostimulating peptide derived from soybean beta-conglycinin alpha' subunit, suppressed alopecia induced by the anti-cancer drug etoposide in neonatal rats. "

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	Etoposide (VP 16)
3.	Glycine max beta-conglycinin protein
4.	NF-kappa B (NF-kB)
5.	Dinoprostone (PGE2)
6.	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
7.	N-Formylmethionine Leucyl-Phenylalanine
8.	Indomethacin (Indometacin)
9.	Histamine Antagonists (Antihistamines)
10.	pyrrolidine dithiocarbamic acid

Related Therapies and Procedures

1.	Oral Administration