8-bromo-cyclic-ADP-ribose

Also Known As:

8-Br-cADPR; 8-bromo-cADPR

Networked: 6 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purine Nucleotides: 140
        Adenine Nucleotides: 1066
        Adenosine Diphosphate: 4554
        Adenosine Diphosphate Sugars
        Adenosine Diphosphate Ribose: 230
        Cyclic ADP-Ribose: 93
        8-bromo-cyclic-ADP-ribose: 6
Carbohydrates: 22023
- Glycosides: 2119
  - Nucleotides: 15763
    - Nucleoside Diphosphate Sugars
      - Adenosine Diphosphate Sugars
        Adenosine Diphosphate Ribose: 230
        Cyclic ADP-Ribose: 93
        8-bromo-cyclic-ADP-ribose: 6
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleotides: 15763
  - Ribonucleotides: 307
    - Adenine Nucleotides: 1066
      - Adenosine Diphosphate: 4554
        Adenosine Diphosphate Sugars
        Adenosine Diphosphate Ribose: 230
        Cyclic ADP-Ribose: 93
        8-bromo-cyclic-ADP-ribose: 6
    - Nucleoside Diphosphate Sugars
      - Adenosine Diphosphate Sugars
        Adenosine Diphosphate Ribose: 230
        Cyclic ADP-Ribose: 93
        8-bromo-cyclic-ADP-ribose: 6
  - Purine Nucleotides: 140
    - Adenine Nucleotides: 1066
      - Adenosine Diphosphate: 4554
        Adenosine Diphosphate Sugars
        Adenosine Diphosphate Ribose: 230
        Cyclic ADP-Ribose: 93
        8-bromo-cyclic-ADP-ribose: 6

Experts

1.	Ai, Mei-Lin: 2 articles (07/2016 - 04/2016)
2.	Ai, Yu-Hang: 2 articles (07/2016 - 04/2016)
3.	Peng, Qian-Yi: 2 articles (07/2016 - 04/2016)
4.	Zhang, Li-Na: 2 articles (07/2016 - 04/2016)
5.	Zou, Yu: 2 articles (07/2016 - 04/2016)
6.	Dipp, M: 2 articles (07/2001 - 04/2001)
7.	Evans, A M: 2 articles (07/2001 - 04/2001)
8.	Eraslan, Ersen: 1 article (01/2019)
9.	Polat, Elif: 1 article (01/2019)
10.	Tanyeli, Ayhan: 1 article (01/2019)

Related Diseases

1.	Sepsis (Septicemia) 04/01/2016 - "Blocking this pathway with 8-Br-cADPR protected hearts, livers, and kidneys from sepsis-induced damage." 04/01/2016 - "The aim of this study was to determine whether the NAD(+)/CD38/cADPR/Ca(2+) signaling pathway is activated during sepsis and whether an inhibitor of this pathway, 8-Br-cADPR, protects the organs from sepsis-induced damage. " 07/20/2016 - "The CD38/cADPR pathway is activated in the lungs of septic rats, and blocking cADPR-mediated calcium overload with 8-Br-cADPR protects against sepsis-induced ALI." 04/01/2016 - "Treatment with 8-Br-cADPR inhibited sepsis-induced intracellular Ca(2+) mobilization, attenuated tissue injury, reduced malondialdehyde levels, and increased superoxide dismutase activity in septic rats. "
2.	Glioma (Gliomas) 05/28/2014 - "Our study showed that both CD38 siRNA and 8-bromo-cADPR - a ryanodine receptor antagonist - can lead to a significant increase in the intracellular ATP levels of C6 glioma cells. "
3.	Hypoxia (Hypoxemia) 07/06/2001 - "Most importantly, we showed that 8-bromo-cADPR blocks HPV induced by alveolar hypoxia in the ventilated rat lung in situ. " 04/06/2001 - "Furthermore, hypoxia induced a 10-fold increase in cADPR levels in pulmonary artery smooth muscle, and a membrane-permeant cADPR antagonist, 8-bromo-cADPR, abolished hypoxic pulmonary vasoconstriction in pulmonary artery rings. "
4.	Reperfusion Injury 01/01/2019 - "CD38, cADPR, tumor necrosis factor-α, interleukin-1β, and myeloperoxidase (inflammatory markers), urea and creatinine, hydrogen peroxide (oxidant), and catalase (antioxidant enzyme) levels that increase with ischemia-reperfusion injury decreased in the groups treated with 8-Br-cADPR. "

Related Drugs and Biologics

1.	Cyclic ADP-Ribose (cADPR)
2.	Small Interfering RNA (siRNA)
3.	Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)
4.	NAD (NADH)
5.	Adenosine Triphosphate (ATP)
6.	Oxidants (Oxidizing Agents)
7.	Urea (Carbamide)
8.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
9.	Superoxide Dismutase
10.	Peroxidase (Myeloperoxidase)