Complement Factor I

A plasma serine proteinase that cleaves the alpha-chains of C3b and C4b in the presence of the cofactors COMPLEMENT FACTOR H and C4-binding protein, respectively. It is a 66-kDa glycoprotein that converts C3b to inactivated C3b (iC3b) followed by the release of two fragments, C3c (150-kDa) and C3dg (41-kDa). It was formerly called KAF, C3bINF, or enzyme 3b inactivator.

Also Known As:

C3b Inactivator; C3b-C4b Inactivator; C4b-C3b-INA; C4bC3bINA; Complement 3b-Complement 4b Inactivator; Complement C4b-C3b Inactivator; C3b C4b Inactivator; C4b C3b INA; C4b-C3b Inactivator, Complement; Complement 3b Complement 4b Inactivator; Complement C4b C3b Inactivator; Inactivator, C3b; Inactivator, C3b-C4b; Inactivator, Complement C4b-C3b

Pharmalogical Action Categories:

Complement Inactivating Agents

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Peptide Hydrolases: 23957
      - Serine Proteases: 3726
        Serine Endopeptidases: 11
        Complement Factor I: 109
      - Endopeptidases: 633
        Serine Endopeptidases: 11
        Complement Factor I: 109
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Immunoproteins: 43
      - Complement System Proteins: 33379
        Complement Inactivator Proteins
        Complement C3b Inactivator Proteins
        Complement Factor I: 109

human CFI protein

Bio-Agent Context: Research Results