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2- ((1,10)phenanthrolin- 2- ylhydrazono)- 3,4- dihydro- 2H- naphthalen- 1- one

has antineoplastic activity; structure in first source

Also Known As:

MEN 15658; MEN-15658; MEN15658

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrazines: 379
  - Hydrazones: 500
    - 2-((1,10)phenanthrolin-2-ylhydrazono)-3,4-dihydro-2H-naphthalen-1-one: 1
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Phenanthrolines: 183
      - 2-((1,10)phenanthrolin-2-ylhydrazono)-3,4-dihydro-2H-naphthalen-1-one: 1

Experts

1.	Bigioni, Mario: 1 article (02/2004)
2.	Binaschi, Monica: 1 article (02/2004)
3.	Camarda, Grazia: 1 article (02/2004)
4.	Goso, Cristina: 1 article (02/2004)
5.	Maggi, Carlo Alberto: 1 article (02/2004)
6.	Salvatore, Carmela: 1 article (02/2004)

Related Diseases

1.	Neoplasms (Cancer) 02/01/2004 - "The compound causes a block in S phase of the cell cycle, inducing apoptotic cell death, thus suggesting an involvement of DNA damage in the MEN15658 effect on tumor cells. " 02/01/2004 - "MEN15658: a new promising anti-tumoral drug active on resistant tumor cells."
2.	Carcinoma (Carcinomatosis) 02/01/2004 - "MEN15658 induces p53 accumulation, and activation of gadd-45, p21, c-fos and bcl-2 family genes in human ovarian carcinoma A2780 cell line. " 02/01/2004 - "We describe the identification of MEN15658, a molecule characterized by a promising cytotoxic effect against human tumor cell lines, including platinum- and anthracycline-resistant ovarian carcinoma. "

Related Drugs and Biologics

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2.	Platinum