HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

ZR2002

combi-molecule designed to block signaling mediated by the ERB family of oncogenes and to damage genomic DNA; structure in first source

Also Known As:

ZR 2002

Networked: 4 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinazolines: 402
      - ZR2002: 4

Experts

1.	Jean-Claude, Bertrand J: 2 articles (04/2020 - 11/2004)
2.	Schmitt, Julie: 2 articles (04/2020 - 12/2019)
3.	Gomes, Izabela N F: 1 article (04/2020)
4.	Goodfellow, Elliot: 1 article (04/2020)
5.	Huang, Shanlong: 1 article (04/2020)
6.	Reis, Rui M: 1 article (04/2020)
7.	Rosa, Marcela N: 1 article (04/2020)
8.	Titi, Hatem M: 1 article (04/2020)
9.	Williams, Christopher: 1 article (04/2020)
10.	Yang, Richard: 1 article (04/2020)

Related Diseases

1.	Brain Neoplasms (Brain Tumor) 12/15/2019 - "ZR2002 improved survival of mice harboring intracranial mesenchymal temozolomide-resistant GSC line, decreased EGFR, Erk1/2, and AKT phosphorylation and was detected in tumor brain tissue by MALDI imaging mass spectrometry. "
2.	Osteosarcoma (Osteogenic Sarcoma) 01/01/2023 - "ZR2002 may well represent a good drug candidate for the treatment of EGFR-expressing osteosarcoma."
3.	Neoplasms (Cancer) 01/01/2023 - "Results: In vivo analysis showed that significant tumor growth inhibition was only achieved when ZR2002 was administered in its naked form. " 01/01/2023 - "Mice were treated with ZR2002, JS84 or JS61, and the tumor burden was measured with a caliper and CT/PET imaging. " 01/01/2023 - "To increase the DNA damage activity in tumor cells in vivo, we compared ZR2002 with two of its 6-N,N-disubstituted analogs: "JS61", with a nitrogen mustard function at the six-position of the quinazoline ring, and "JS84", with an N-methyl group. "
4.	Lung Neoplasms (Lung Cancer) 04/15/2020 - "ZR2002 and JS84) showed stronger EGFR and growth inhibitory potency than JS61 in a panel of lung cancer cells. "
5.	Breast Neoplasms (Breast Cancer) 11/10/2004 - "Multiple mechanisms of action of ZR2002 in human breast cancer cells: a novel combi-molecule designed to block signaling mediated by the ERB family of oncogenes and to damage genomic DNA."

Related Drugs and Biologics

1.	Temozolomide (Temodar)
2.	Quinazolines
3.	Mechlorethamine (Nitrogen Mustard)
4.	DNA (Deoxyribonucleic Acid)