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4,5-dihydroxy-2,3-pentanedione

structure in first source

Also Known As:

1-deoxypentosone; 4,5-DHP

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Acyclic Hydrocarbons
    - Alkanes: 241
      - Pentanes
        4,5-dihydroxy-2,3-pentanedione: 3

Experts

1.	Stevenson, Brian: 2 articles (04/2015 - 07/2007)
2.	Antonicello, Alyssa D: 1 article (04/2015)
3.	Arnold, William K: 1 article (04/2015)
4.	Savage, Christina R: 1 article (04/2015)
5.	Cvitkovitch, Dennis G: 1 article (01/2008)
6.	Geffers, Robert: 1 article (01/2008)
7.	Lemme, André: 1 article (01/2008)
8.	Levesque, Celine M: 1 article (01/2008)
9.	Schulz, Stefan: 1 article (01/2008)
10.	Sztajer, Helena: 1 article (01/2008)

Related Diseases

1.	Lyme Disease (Disease, Lyme) 07/01/2007 - "The Lyme disease spirochaete, Borrelia burgdorferi, produces the LuxS enzyme both in vivo and in vitro; this enzyme catalyses the synthesis of homocysteine and 4,5-dihydroxy-2,3-pentanedione (DPD) from a by-product of methylation reactions. "
2.	Infections 04/01/2015 - "burgdorferi synthesizes 4,5-dihydroxy-2,3-pentanedione (autoinducer-2 [AI-2]) and responds to AI-2 by measurably changing production of several infection-associated proteins. "
3.	Dental Plaque 01/01/2008 - "To separate the metabolic function of the LuxS enzyme from the signaling role of AI-2, we carried out a global transcriptome analysis of a luxS null mutant culture of Streptococcus mutans UA159, an important cariogenic bacterium and a crucial component of the dental plaque biofilm community, in comparison to a luxS null mutant culture supplemented with chemically pure 4,5-dihydroxy-2,3-pentanedione, the precursor of AI-2. "

Related Drugs and Biologics

1.	Enzymes
2.	Proteins (Proteins, Gene)
3.	Homocysteine
4.	N-octanoylhomoserine lactone