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nitrosofenfluramine

structure in first source

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Ethylamines: 5
    - Phenethylamines: 28
      - Fenfluramine: 954
        nitrosofenfluramine: 7

Experts

1.	Nakagawa, Yoshio: 3 articles (12/2006 - 06/2005)
2.	Suzuki, Toshinari: 3 articles (12/2006 - 06/2005)
3.	Nagai, Fumiko: 3 articles (09/2006 - 06/2005)
4.	Ogata, Akio: 2 articles (12/2006 - 09/2006)
5.	Kamimura, Hisashi: 2 articles (01/2006 - 06/2005)
6.	Ishii, Hidemi: 1 article (12/2006)
7.	Tayama, Sumiko: 1 article (12/2006)
8.	Fukumori, Nobutaka: 1 article (09/2006)
9.	Nonaka, Ryouichi: 1 article (09/2006)
10.	Satoh, Kanako: 1 article (09/2006)

Related Diseases

1.	Weight Loss (Weight Reduction) 09/01/2006 - "Effects of N-nitrosofenfluramine, a component of Chinese dietary supplement for weight loss, on CD-1 mice." 03/01/2004 - "Severe hepatotoxicity associated with a N-nitrosofenfluramine-containing weight-loss supplement: report of three cases." 09/01/2006 - "Many cases of hepatopathy including deaths have frequently occurred after ingestion of Chinese dietary supplements for weight loss containing N-nitrosofenfluramine (N-fen), a nitroso derivative of fenfluramine (Fen), which was used for the treatment of obesity in the United States. "
2.	Blister (Bulla) 01/04/2006 - "The pretreatment of isolated hepatocytes with cyclosporin A (2 microM) partially but not completely prevented N-nitrosofenfluramine (0.6 mM; a low toxic dose)-induced cell death, loss of cellular ATP, formation of cell blebs and decrease in mitochondrial membrane potential. " 12/01/2006 - "The supplementation of fructose, an ATP-generating glycolytic substrate, to hepatocyte suspensions prevented N-nitrosofenfluramine-induced cell injury accompanied by the formation of cell blebs, abrupt loss of intracellular ATP and reduced glutathione and mitochondrial membrane potential (DeltaPsi), and the accumulation of oxidized glutathione and malondialdehyde, indicating lipid peroxidation, during a 2h incubation period. "
3.	Mitochondrial Diseases (Mitochondrial Disease) 06/01/2005 - "N-Nitrosofenfluramine induces cytotoxicity via mitochondrial dysfunction and oxidative stress in isolated rat hepatocytes." 06/01/2005 - "These results indicate that (a) mitochondria are target organelles for N-nitrosofenfluramine, which elicits cytotoxicity through mitochondrial dysfunction related to membrane potential and/or oxidative phosphorylation at an early stage and subsequently lipid peroxidation at a later stage; and (b) the toxicity of N-nitrosofenfluramine is greater than that of fenfluramine, suggesting participation of the nitroso group in the toxicity."
4.	Liver Failure 07/01/2004 - "A fatal case of hepatic failure possibly induced by nitrosofenfluramine: a case report."
5.	Obesity 09/01/2006 - "Many cases of hepatopathy including deaths have frequently occurred after ingestion of Chinese dietary supplements for weight loss containing N-nitrosofenfluramine (N-fen), a nitroso derivative of fenfluramine (Fen), which was used for the treatment of obesity in the United States. "

Related Drugs and Biologics

1.	Fenfluramine
2.	Adenosine Triphosphate (ATP)
3.	Glutathione Disulfide (GSSG)
4.	Cyclosporine (Ciclosporin)
5.	Suspensions
6.	Nitrosamines
7.	Malondialdehyde (Propanedial)
8.	Glutathione (Reduced Glutathione)
9.	Fructose