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1,1- bis(3'- indolyl)- 1- (4- trifluoromethylphenyl)methane

a peroxisome proliferator-activated receptor gamma (PPARgamma) agonist; structure in first osurce

Also Known As:

1,1-bis(3'-indolyl)-1-(p-trifluoromethylphenyl)methane; DIM-C-pPhCF3

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - 1,1-bis(3'-indolyl)-1-(4-trifluoromethylphenyl)methane: 2

Experts

1.	Abdelrahim, Maen: 2 articles (01/2006 - 12/2004)
2.	Safe, Stephen: 2 articles (01/2006 - 12/2004)
3.	Chintharlapalli, Sudhakar: 1 article (01/2006)
4.	Kamat, Ashish M: 1 article (01/2006)
5.	Kassouf, Wassim: 1 article (01/2006)
6.	Nelkin, Gina: 1 article (01/2006)
7.	Hong, Jun: 1 article (12/2004)
8.	Liu, Shengxi: 1 article (12/2004)
9.	Samudio, Ismael: 1 article (12/2004)

Related Diseases

1.	Pancreatic Neoplasms (Pancreatic Cancer) 12/01/2004 - "1,1-Bis(3'-indolyl)-1-(p-trifluoromethylphenyl)methane (DIM-C-pPhCF3) and troglitazone activate peroxisome proliferator-activated receptor gamma (PPARgamma) in Panc-28 pancreatic cancer cells and also inhibit cell proliferation. "
2.	Urinary Bladder Neoplasms (Bladder Cancer) 01/01/2006 - "Treatment of KU7 cells with DIM-C-pPhCF3 also elevated caveolin-1 expression by 25% to 30%, suggesting a role for this protein in mediating the antitumorigenic activity of DIM-C-pPhCF3 in bladder cancer."

Related Drugs and Biologics

1.	Caveolin 1
2.	PPAR gamma
3.	Proteins (Proteins, Gene)
4.	Troglitazone (Rezulin)