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6-nitro-7-hydroxycoumarin

has antineoplastic activity

Also Known As:

6-NO2-7-OHC

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Nitro Compounds: 66
  - 6-nitro-7-hydroxycoumarin: 3
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Coumarins: 826
        Umbelliferones: 3
        6-nitro-7-hydroxycoumarin: 3
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Coumarins: 826
        Umbelliferones: 3
        6-nitro-7-hydroxycoumarin: 3

Experts

1.	Creaven, Bernadette S: 2 articles (09/2005 - 03/2004)
2.	Egan, Denise A: 2 articles (09/2005 - 03/2004)
3.	Finn, Gregory J: 2 articles (09/2005 - 03/2004)
4.	Creaven, Bernadette: 1 article (11/2003)
5.	Egan, Denise: 1 article (11/2003)
6.	Finn, Gregory: 1 article (11/2003)

Related Diseases

1.	Renal Cell Carcinoma (Grawitz Tumor) 03/08/2004 - "Previously, 7-hydroxycoumarin (7-OHC) and 6-nitro-7-hydroxycoumarin (6-NO2-7-OHC) have been shown to be potent and selective anti-proliferative agents to the human renal cell carcinoma (RCC) cell line, A-498. " 11/28/2003 - "Modulation of mitogen-activated protein kinases by 6-nitro-7-hydroxycoumarin mediates apoptosis in renal carcinoma cells." 11/28/2003 - "In summary, this study shows the participation of p38 MAP kinase in 6-nitro-7-hydroxycoumarin induced apoptosis of A-498 cells and suggests that targeting of p38 may represent a novel mechanism to inhibit renal cell carcinoma and that coumarin type drugs require further investigation as potential anticancer agents directed against renal cell carcinoma." 11/28/2003 - "6-Nitro-7-hydroxycoumarin has previously been shown to be a selective anti-proliferative agent capable of activating p38, stress-activated protein kinase (SAPK) and mitogen-activated protein (MAP) kinase in the human renal cell carcinoma cell line, A-498. "
2.	Melanoma (Melanoma, Malignant) 09/01/2005 - "6-Nitro-7-hydroxycoumarin (6-NO2-7-OHC) and 3,6,8-trinitro-7-hydroxycoumarin (3,6,8-NO2-7-OHC) have previously been shown to be potent and selective anti-proliferative agents in a human melanoma cell line. "

Related Drugs and Biologics

1.	p38 Mitogen-Activated Protein Kinases
2.	Antineoplastic Agents (Antineoplastics)
3.	coumarin
4.	Mitogen-Activated Protein Kinases
5.	Proteins (Proteins, Gene)
6.	Protein Kinases (Protein Kinase)
7.	Phosphotransferases (Kinase)
8.	Mitogens
9.	3,6,8-trinitro-7-hydroxycoumarin
10.	7-hydroxycoumarin (umbelliferone)