1- (4- chlorophenyl)- 3- (3- (4- chlorophenyl)- 5,5- dimethyl- 1- (3- (5- nitrofuran- 2- yl)allyldienehydrazinocarbonylmethyl)- 2- oxoimidazolidin- 4- yl)- 1- hydroxyurea

stabilizes dislocation substrates in the endoplasmic reticulum membrane and thereby affects degradation of misfolded type I membrane proteins; structure in first source

Also Known As:

eeyarestatin I

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Urea: 15015
    - Hydroxyurea: 3694
      - 1-(4-chlorophenyl)-3-(3-(4-chlorophenyl)-5,5-dimethyl-1-(3-(5-nitrofuran-2-yl)allyldienehydrazinocarbonylmethyl)-2-oxoimidazolidin-4-yl)-1-hydroxyurea: 5
- Hydrazines: 379
  - Hydrazones: 500
    - 1-(4-chlorophenyl)-3-(3-(4-chlorophenyl)-5,5-dimethyl-1-(3-(5-nitrofuran-2-yl)allyldienehydrazinocarbonylmethyl)-2-oxoimidazolidin-4-yl)-1-hydroxyurea: 5

Experts

1.	Ye, Yihong: 2 articles (11/2016 - 11/2010)
2.	Kong, JiaWei: 1 article (01/2022)
3.	Li, ShaSha: 1 article (01/2022)
4.	Liu, QiFeng: 1 article (01/2022)
5.	Yu, LiXia: 1 article (01/2022)
6.	Chen, Liqiang: 1 article (11/2016)
7.	Ding, Rui: 1 article (11/2016)
8.	Williams, Jessica: 1 article (11/2016)
9.	Xie, Jiashu: 1 article (11/2016)
10.	Zhang, Ting: 1 article (11/2016)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2016 - "Eeyarestatin I (EerI) blocks p97 through a novel mechanism of action and has favorable anti-cancer activities against cultured cancer cells. " 11/12/2010 - "We recently reported that the ERAD inhibitor Eeyarestatin I (EerI) also disturbs ER homeostasis and has anti-cancer activities resembling that of Bortezomib. "
2.	Ureteral Obstruction 01/01/2022 - "Methods: Following establishment of a mouse RIF model by unilateral ureteral obstruction (UUO), a specific ERAD inhibitor, Eeyarestatin I (EerI), was administered to experimental animals by intraperitoneal injection. "
3.	Retinal Degeneration 08/26/2010 - "Pharmacological treatment of Rh1(P37H) flies with the VCP/ERAD inhibitor Eeyarestatin I or with the proteasome inhibitor MG132 also led to a strong suppression of retinal degeneration. "
4.	Lung Neoplasms (Lung Cancer) 07/10/2015 - "Further, brief treatment of cells with eeyarestatin I increases EMT markers, and migratory and invasive properties of lung cancer cells. "

Related Drugs and Biologics

1.	Proteasome Inhibitors
2.	Bortezomib (Velcade)
3.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde

Related Therapies and Procedures

1.	Intraperitoneal Injections