|1.||Gourdeau, Henriette: 2 articles (01/2010 - 05/2008)|
|2.||Falardeau, Pierre: 2 articles (01/2010 - 05/2008)|
|3.||Mason, Warren P: 1 article (04/2012)|
|4.||Omuro, Antonio: 1 article (04/2012)|
|5.||Mathieu, David: 1 article (04/2012)|
|6.||Belanger, Karl: 1 article (04/2012)|
|7.||Desjardins, Annick: 1 article (04/2012)|
|8.||Nicholas, Garth: 1 article (04/2012)|
|9.||Vallières, Isabelle: 1 article (04/2012)|
|10.||Kavan, Petr: 1 article (04/2012)|
|1.||Glioblastoma (Glioblastoma Multiforme)
11/15/2010 - "Taken together our data indicate that while PBR binding does not mediate cell growth inhibition and apoptosis, PBR binding may allow for the specific accumulation of TLN-4601 in PBR positive tumors."
11/15/2010 - "TLN-4601 accumulation in the tumor (176 μg/g) was also significant compared to liver (24.8 μg/g; 7-fold) and plasma (16.2 μg/mL; 11-fold). "
11/15/2010 - "Analysis of TLN-4601 tissue and plasma indicated that TLN-4601 preferentially accumulates in the tumor. "
11/15/2010 - "TLN-4601 is a farnesylated dibenzodiazepinone isolated from Micromonospora sp. with an antiproliferative effect on several human cancer cell lines. "
01/01/2010 - "Finally, treatment of MIA PaCa-2 tumor-bearing mice with TLN-4601 resulted in antitumor activity and decreased tumor Raf-1 protein levels. "
05/01/2008 - "The ability of ECO-4601 to inhibit the growth of CNS cancers was evaluated on a panel of mouse, rat and human glioma cell lines using a standard MTT assay. "
04/01/2012 - "TLN-4601 inhibits the Ras-MAPK signaling pathway, and in animal models crosses the blood-brain barrier and accumulates in implanted gliomas, possibly by binding specifically to the peripheral benzodiazepine receptor. "
05/01/2008 - "In a rat glioma (C6) xenograft model, ECO-4601 produced up to 70% tumor growth inhibition (TGI) while in a human glioma (U-87MG) xenograft, TGI was 34%. "
|4.||Brain Neoplasms (Brain Tumor)
|5.||Pancreatic Neoplasms (Pancreatic Cancer)
|1.||GABA-A Receptors (GABA(A) Receptor)
|1.||Heterologous Transplantation (Xenotransplantation)