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((1S)- 1- (((7- bromo- 1,2,3,4- tetrahydro- 2,3- dioxo- 5- quinoxalinyl)methyl)amino)ethyl)phosphonate

a glycine site-specific N-methyl-D-aspartate receptor antagonist prevents activation of the NMDA/NO/CGMP pathway by ammonia

Also Known As:

CGP 78608

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinoxalines: 324
      - ((1S)-1-(((7-bromo-1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl)amino)ethyl)phosphonate: 1
Organic Chemicals: 133
- Organophosphorus Compounds: 300
  - Organophosphonates: 424
    - ((1S)-1-(((7-bromo-1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl)amino)ethyl)phosphonate: 1

Experts

1.	Dewey, William L: 1 article (07/2007)
2.	Gabra, Bichoy H: 1 article (07/2007)
3.	Kessler, Fay K: 1 article (07/2007)
4.	Ritter, Joseph K: 1 article (07/2007)
5.	Smith, Forrest L: 1 article (07/2007)

Related Diseases

1.

07/01/2007 - "with CGS 19755 (selective antagonist of the NMDAR), CGP 78608 [[(1S)-1-[[(7-bromo-1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl]amino]ethyl]phosphonic acid] (selective antagonist at the glycine-binding site of the NMDAR), ifenprodil and Ro 25-6981 (selective antagonists of the NR2B subunit of the NMDAR), bisindolylmaleimide I and Go-7874 [12-(2-cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo(2,3-a)pyrrolo(3,4-c)-carbazole] (inhibitors of protein kinase C), or PKI-(14-22)-amide [Myr-N-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH(2)] (inhibitor of protein kinase A) dose-dependently inhibited the hyperalgesia induced by i.t. "

Related Drugs and Biologics

1.	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)
2.	Protein Kinase C
3.	Glycine (Aminoacetic Acid)
4.	phosphonic acid
5.	threonyl-glycine
6.	Ro 25-6981
7.	arginylarginine (Arg-Arg)
8.	bisindolylmaleimide I
9.	selfotel
10.	carbazole